Riluzole Series. Synthesis and in Vivo “Antiglutamate” Activity of 6-Substituted-2-benzothiazolamines and 3-Substituted-2-imino-benzothiazolines

Patrick Jimonet, F. AUDIAU, Michel Barreau, +28

Journal of Medicinal Chemistry

Bioorganic ChemistryOrganic ChemistryPharmacotherapyHeterocycle ChemistryExperimental Pharmacology +16

Neuroprotective actions of riluzole in rodent models of global and focal cerebral ischaemia

Jeremy Pratt, Jean Rataud, Florence Bardot, +4

Neuroscience Letters

Neuroprotective ActionsNeurophysiologyMedicineRodent ModelsNeuropharmacology +12

Comparative study of voltage-sensitive sodium channel blockers in focal ischaemia and electric convulsions in rodents

Jean Rataud, Florence Debarnot, Véronique Mary, +2

Neuroscience Letters

Focal IschaemiaHyperpolarization (Biology)Sodium HomeostasisNeurophysiologyPhysiology +10

The effect of riluzole on post-traumatic spinal cord injury in the rat

Jean‐Marie Stutzmann, Jeremy Pratt, Thomas Boraud, +1

Neuroreport

NeurorehabilitationNeuroregenerationSpinal Cord InjuryAnesthesiaPeripheral Nerve Injury +13

RPR 119990, a novel alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid antagonist: synthesis, pharmacological properties, and activity in an animal model of amyotrophic lateral sclerosis.

Thierry Canton, Böhme Ga, Alain Boireau, +16

PubMed

NeurotransmitterBrain PenetrationRpr 119990Experimental PharmacologyNeurology +15

Glutamate uptake is decreased tardively in the spinal cord of FALS mice

Thierry Canton, Jeremy Pratt, Jean‐Marie Stutzmann, +2

Neuroreport

Glutamate Uptake DeficiencyNeurotransmitterNeurologyNeuropathologyNeurochemistry +14

RPR 119990, a Novel α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid Antagonist: Synthesis, Pharmacological Properties, and Activity in an Animal Model of Amyotrophic Lateral Sclerosis

Thierry Canton, Georg Andrees Böhme, Alain Boireau, +16

Journal of Pharmacology and Experimental Therapeutics

Riluzole prolongs survival and delays muscle strength deterioration in mice with progressive motor neuronopathy (pmn)

Philippe Kennel, Frédéric Revah, Georg Andrees Böhme, +5

Journal of the Neurological Sciences

Muscle FunctionMuscle InjurySkeletal MuscleMedicinePhysiology +6

9-Carboxymethyl-5H,10H-imidazo[1,2-a]indeno[1,2-e]pyrazin-4-one-2-carbocylic Acid (RPR117824): Selective Anticonvulsive and Neuroprotective AMPA Antagonist

Serge Mignani, Georg Andrees Böhme, Guillaume Birraux, +9

Bioorganic & Medicinal Chemistry

Neuroprotective Profile of Riluzole in In Vivo Models of Acute Neurodegenerative Diseases

J.M. Stutzmann, Florence Wahl, Jeremy Pratt, +4

CNS Drug Reviews

Neurodegenerative DiseasesVivo ModelsAlzheimer's DiseaseNeuroprotective ProfileMedicine +10