Jason M. Fye

Exonuclease TREX1 degrades double-stranded DNA to prevent spontaneous lupus-like inflammatory disease

Jessica Grieves, Jason M. Fye, Scott Harvey et al. · Proceedings of the National Academy of Sciences · 2015 · 178 citations · Full text

Life Sciences, Immunology, Molecular Biology +16

Dominant Mutations of the TREX1 Exonuclease Gene in Lupus and Aicardi-Goutières Syndrome

Jason M. Fye, Clinton D. Orebaugh, Stephanie R. Coffin et al. · Journal of Biological Chemistry · 2011 · 78 citations · Full text

Life Sciences, Genetics, Molecular Genetics +12

The TREX1 Exonuclease R114H Mutation in Aicardi-Goutières Syndrome and Lupus Reveals Dimeric Structure Requirements for DNA Degradation Activity

Clinton D. Orebaugh, Jason M. Fye, Scott Harvey et al. · Journal of Biological Chemistry · 2011 · 46 citations · Full text

Life Sciences, Genetics, Molecular Biology +10

The TREX1 C-terminal Region Controls Cellular Localization through Ubiquitination

Clinton D. Orebaugh, Jason M. Fye, Scott Harvey et al. · Journal of Biological Chemistry · 2013 · 45 citations · Full text

Life Sciences, Cell Biology, Molecular Biology +4

Multifaceted role of TREX2 in the skin defense against UV-induced skin carcinogenesis

Joan Manils, Diana Gómez, Mercè Salla‐Martret et al. · Oncotarget · 2015 · 18 citations · Full text

Medicine, Dermatology, Oncology +15