John G. Dann

Large-scale purification and characterization of dihydrofolate reductase from a methotrexate-resistant strain of <i>Lactobacillus casei</i>

John G. Dann, G. Ostler, Richard A. Bjur et al. · Biochemical Journal · 1976 · 151 citations · Full text

Methotrexate-resistant Strain, Biosynthesis, Engineering +15

Receptor-based design of dihydrofolate reductase inhibitors: comparison of crystallographically determined enzyme binding with enzyme affinity in a series of carboxy-substituted trimethoprim analogs

Lee F. Kuyper, Barbara Roth, David P. Baccanari et al. · Journal of Medicinal Chemistry · 1985 · 108 citations · Full text

The structure of mouse L1210 dihydrofolate reductase‐drug complexes and the construction of a model of human enzyme

D.K. Stammers, J.N. Champness, C.R. Beddell et al. · FEBS Letters · 1987 · 89 citations · Full text

Receptor-based design of dihydrofolate reductase inhibitors: comparison of crystallographically determined enzyme binding with enzyme affinity in a series of carboxy-substituted trimethoprim analogs

Lee F. Kuyper, Barbara Roth, David P. Baccanari et al. · Journal of Medicinal Chemistry · 1982 · 79 citations

Molecular Pharmacology, Medicinal Chemistry, Receptor-based Design +15

Nuclear magnetic resonance studies of the binding of substrate analogs and coenzyme to dihydrofolate reductase from Lactobacillus casei

Gordon C. K. Roberts, J. Feeney, A. S. V. Burgen et al. · Biochemistry · 1974 · 37 citations

Bioorganic Chemistry, Altmetric Attention Score, Molecular Biology +19