Lorena T. Davies

From Sphingosine Kinase to Dihydroceramide Desaturase: A Structure–Activity Relationship (SAR) Study of the Enzyme Inhibitory and Anticancer Activity of 4-((4-(4-Chlorophenyl)thiazol-2-yl)amino)phenol (SKI-II)

Luigi Aurelio, Carmen V. Scullino, Melissa R. Pitman et al. · Journal of Medicinal Chemistry · 2016 · 64 citations · Full text

Medicine, Oncology, Pharmacology +15

Sphingosine kinase 2 inhibition synergises with bortezomib to target myeloma by enhancing endoplasmic reticulum stress

Craig T. Wallington‐Beddoe, Melissa K. Bennett, Kate Vandyke et al. · Oncotarget · 2017 · 44 citations · Full text

Medicine, Oncology, Pharmacology +16

CIB2 Negatively Regulates Oncogenic Signaling in Ovarian Cancer via Sphingosine Kinase 1

Wenying Zhu, Kate E. Jarman, Noor A. Lokman et al. · Cancer Research · 2017 · 31 citations · Full text

Life Sciences, Cell Biology, Oncology +17

Reduction in sphingosine kinase 1 influences the susceptibility to dengue virus infection by altering antiviral responses

Jennifer N. Clarke, Lorena T. Davies, Julie K. Calvert et al. · Journal of General Virology · 2015 · 22 citations

Life Sciences, Infectious Diseases, Molecular Biology +17

The sphingosine 1-phosphate receptor 2/4 antagonist JTE-013 elicits off-target effects on sphingolipid metabolism

Melissa R. Pitman, Alexander C. Lewis, Lorena T. Davies et al. · Scientific Reports · 2022 · 19 citations · Full text

Life Sciences, Biochemistry, Pharmacology +17