Alexander C. Lewis

Interleukin-5, interleukin-3, and granulocyte-macrophage colony-stimulating factor cross-compete for binding to cell surface receptors on human eosinophils.

Angel F. López, Mathew A. Vadas, Joanna M. Woodcock et al. · Journal of Biological Chemistry · 1991 · 132 citations · Full text

Immune Regulation, Immunology, Immunologic Mechanism +19

ROCK-mediated selective activation of PERK signalling causes fibroblast reprogramming and tumour progression through a CRELD2-dependent mechanism

Sarah T. Boyle, Valentina Poltavets, Jasreen Kular et al. · Nature Cell Biology · 2020 · 99 citations

Tumor Biology, Signal Transduction, Signaling Pathway +12

Targeting sphingosine kinase 1 induces MCL1-dependent cell death in acute myeloid leukemia

Jason A. Powell, Alexander C. Lewis, Wenying Zhu et al. · Blood · 2016 · 85 citations · Full text

Targeting sphingolipid metabolism as an approach for combination therapies in haematological malignancies

Alexander C. Lewis, Craig T. Wallington‐Beddoe, Jason A. Powell et al. · Cell Death Discovery · 2018 · 74 citations · Full text

Ceramide-induced integrated stress response overcomes Bcl-2 inhibitor resistance in acute myeloid leukemia

Alexander C. Lewis, Victoria S. Pope, Melinda N. Tea et al. · Blood · 2022 · 44 citations · Full text

Hematological Malignancy, Sphingolipid Ceramide, Oncology +15