E M Cretton

Catabolism of 3'-azido-3'-deoxythymidine in hepatocytes and liver microsomes, with evidence of formation of 3'-amino-3'-deoxythymidine, a highly toxic catabolite for human bone marrow cells.

E M Cretton, Mengyu Xie, Ruth Bevan et al. · Molecular Pharmacology · 1991 · 106 citations

Clinical pharmacokinetics of 3′-azido-3′-deoxythymidine (zidovudine) and catabolites with formation of a toxic catabolite, 3′-amino-3′-deoxythymidine

M. Patrick Stagg, E M Cretton, Lauren B. Kidd et al. · Clinical Pharmacology & Therapeutics · 1992 · 93 citations

Unchanged Drug, Molecular Pharmacology, Pharmacological Study +13

Pharmacokinetics of 3'-azido-3'-deoxythymidine and its catabolites and interactions with probenecid in rhesus monkeys

E M Cretton, Raymond F. Schinazi, Harold M. McClure et al. · Antimicrobial Agents and Chemotherapy · 1991 · 52 citations · Full text

Medicinal Chemistry, Apparent Half-life, Pharmacological Study +13

In vitro and in vivo disposition and metabolism of 3'-deoxy-2',3'-didehydrothymidine

E M Cretton, Z Zhou, Lauren B. Kidd et al. · Antimicrobial Agents and Chemotherapy · 1993 · 39 citations

Vivo Disposition, Nonhuman Primates, Toxicological Mechanism +17

Reduction of 3′-azido-3′-deoxythymidine to 3′-amino-3′-deoxythymidine in human liver microsomes and its relationship to cytochrome P450

L Placidi, E M Cretton, M. Placidi et al. · Clinical Pharmacology & Therapeutics · 1993 · 32 citations