Involvement of human liver cytochrome P450 3A in vinblastine metabolism: drug interactions.

Xin-Ru Zhou-Pan, Eric Sérée, Xiaojing Zhou, +4

PubMed

Metabolomic ProfilingSecondary MetaboliteToxicological MechanismMolecular PharmacologyCytochrome P450 3A +19

Characterization of midazolam metabolism using human hepatic musomal fractions and hepatocytes in suspension obtained by perfusing whole human livers

Gérard Fabre, Roger Rahmani, M. Placidi, +6

Biochemical Pharmacology

HepatologyWhole Human LiversMedicineLiver PhysiologyHepatotoxicity +5

Human liver microsomal cytochrome P450 3A isozymes mediated vindesine biotransformation

Xiaojian Zhou, Xin-Ru Zhou-Pan, Thérése Gauthier, +3

Biochemical Pharmacology

Vindesine BiotransformationHepatologyBiochemistryMedicineLiver Physiology +10

Thawed human hepatocytes in primary culture

Mengjia Dou, Georges de Sousa, Bruno Lacarelle, +5

Cryobiology

HepatologyLiver PhysiologyHistopathologyCell CultureLiver Disease +5

Metabolism of digoxin, digoxigenin digitoxosides and digoxigenin in human hepatocytes and liver microsomes

Bruno Lacarelle, Roger Rahmani, Georges de Sousa, +3

Fundamental and Clinical Pharmacology

Identification of the human and animal hepatic cytochromes P450 involved in clonazepam metabolism

EJ Seree, PJ Pisano, M. Placidi, +2

Fundamental and Clinical Pharmacology

Tissue-specific expression and methylation of the human CYP2E1 gene

Florence Botto, Eric Sérée, Saı̈d El Khyari, +7

Biochemical Pharmacology

Epigenetic ChangeGeneticsDna MethylationEpigenomicsGene Expression +3

A multicentre study of acute in vitro cytotoxicity in rat liver cells

Alain Fautrel, Christophe Chesné, A. Guillouzo, +19

Toxicology in Vitro

Rat Liver CellsHepatologyMedicineLiver PhysiologyMulticentre Study +13

In vivo and in vitro pharmacokinetics and metabolism of vincaalkaloids in rat II. Vinblastine and Vincristine

Xiaoyu Zhou, Marie Martin, M. Placidi, +2

European Journal of Drug Metabolism and Pharmacokinetics

Pharmacological StudyMedicineHerb-drug InteractionExperimental PharmacologyPharmacotherapy +4

Disposition and metabolism of the angiogenic moderator O-(chloroacetyl-carbamoyl) fumagillol (TNP-470; AGM-1470) in human hepatocytes and tissue microsomes.

L Placidi, E. Cretton‐Scott, Georges de Sousa, +3

PubMed

Lipid PeroxidationSecondary MetaboliteExtensive MetabolismAngiogenic Moderator O-Oxidative Stress +17