William E. Perkins

Synthesis and Biological Evaluation of the 1,5-Diarylpyrazole Class of Cyclooxygenase-2 Inhibitors:  Identification of 4-[5-(4-Methylphenyl)-3- (trifluoromethyl)-1<i>H</i>-pyrazol-1-yl]benzenesulfonamide (SC-58635, Celecoxib)

Thomas D. Penning, John J. Talley, Stephen R. Bertenshaw et al. · Journal of Medicinal Chemistry · 1997 · 2K citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17

4-[5-Methyl-3-phenylisoxazol-4-yl]- benzenesulfonamide, Valdecoxib:  A Potent and Selective Inhibitor of COX-2

John J. Talley, David Brown, Jeffery S. Carter et al. · Journal of Medicinal Chemistry · 2000 · 643 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +8

1,2-Diarylimidazoles as Potent, Cyclooxygenase-2 Selective, and Orally Active Antiinflammatory Agents

Ish Khanna, Richard M. Weier, Yi Yu et al. · Journal of Medicinal Chemistry · 1997 · 153 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +15

Selective Cyclooxygenase Inhibitors: Novel 1,2-Diarylcyclopentenes Are Potent and Orally Active COX-2 Inhibitors

David B. Reitz, James J. Li, Monica B. Norton et al. · Journal of Medicinal Chemistry · 1994 · 118 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +7

Selective Cyclooxygenase-2 Inhibitors:  Heteroaryl Modified 1,2-Diarylimidazoles Are Potent, Orally Active Antiinflammatory Agents

Ish Khanna, Yi Yu, Renee M. Huff et al. · Journal of Medicinal Chemistry · 2000 · 111 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +11