Identification and Characterization of MEDI4736, an Antagonistic Anti–PD-L1 Monoclonal Antibody

Ross Stewart, Michelle Morrow, Scott A. Hammond, +18

Cancer Immunology Research

ImmunologyImmunoeditingImmunologic MechanismImmunotherapyTumor Biology +18

Targeting CD73 in the tumor microenvironment with MEDI9447

Carl Hay, Erin Sult, Qihui Huang, +15

OncoImmunology

Adenovirus Serotype 5 Fiber Shaft Influences <i>In Vivo</i> Gene Transfer in Mice

Theodore A Smith, Neeraja Idamakanti, Michele L. Rollence, +6

Human Gene Therapy

Intratumoral IL12 mRNA Therapy Promotes TH1 Transformation of the Tumor Microenvironment

Susannah L. Hewitt, D. R. Shackleton Bailey, John Zielinski, +29

Clinical Cancer Research

Design and Efficacy of a Monovalent Bispecific PD-1/CTLA4 Antibody That Enhances CTLA4 Blockade on PD-1+ Activated T Cells

Simon J. Dovedi, Matthew J. Elder, Chunning Yang, +32

Cancer Discovery

Antibody–Drug Conjugates Bearing Pyrrolobenzodiazepine or Tubulysin Payloads Are Immunomodulatory and Synergize with Multiple Immunotherapies

Jonathan Rios‐Doria, Jay Harper, Raymond Rothstein, +17

Cancer Research

Enhanced tumor-targeting selectivity by modulating bispecific antibody binding affinity and format valence

Yariv Mazor, Kris F. Sachsenmeier, Chunning Yang, +5

Scientific Reports

Direct targeting of αvβ3 integrin on tumor cells with a monoclonal antibody, Abegrin™

Kathy Mulgrew, Krista Kinneer, Xiao-Tao Yao, +9

Molecular Cancer Therapeutics

Integrin Alphavbeta3MedicineTumor GrowthImmunologyAlphavbeta3 Integrin +13

CEA/CD3 bispecific antibody MEDI-565/AMG 211 activation of T cells and subsequent killing of human tumors is independent of mutations commonly found in colorectal adenocarcinomas

Michael D. Oberst, Stacy Fuhrmann, Kathy Mulgrew, +7

mAbs

ImmunologyImmunoeditingPathologyT CellsCancer Biology +15

Resistance to Durvalumab and Durvalumab plus Tremelimumab Is Associated with Functional <i>STK11</i> Mutations in Patients with Non–Small Cell Lung Cancer and Is Reversed by STAT3 Knockdown

Nabendu Pore, Song Wu, Nathan Standifer, +22

Cancer Discovery