Effects of androgens on adipocyte differentiation and adipose tissue explant metabolism in men and women

Karine Blouin, Mélanie Nadeau, Martin Perreault, +6

Clinical Endocrinology

Role of Glucuronidation for Hepatic Detoxification and Urinary Elimination of Toxic Bile Acids during Biliary Obstruction

Martin Perreault, Andrzej Białek, Jocelyn Trottier, +4

PLoS ONE

GastroenterologyPathologyUnconjugated BasOxidative StressHepatotoxicity +18

The Human UDP-Glucuronosyltransferase UGT2A1 and UGT2A2 Enzymes Are Highly Active in Bile Acid Glucuronidation

Martin Perreault, Louis Gauthier-Landry, Jocelyn Trottier, +4

Drug Metabolism and Disposition

Design of a Mestranol 2‐<i>N</i>‐Piperazino‐Substituted Derivative Showing Potent and Selective in vitro and in vivo Activities in MCF‐7 Breast Cancer Models

Martin Perreault, René Maltais, Jenny Roy, +2

ChemMedChem

The Human UGT1A3 Enzyme Conjugates Norursodeoxycholic Acid into a C23-ester Glucuronide in the Liver

Jocelyn Trottier, Diala El Husseini, Martin Perreault, +10

Journal of Biological Chemistry

Urinary Elimination of Bile Acid Glucuronides under Severe Cholestatic Situations: Contribution of Hepatic and Renal Glucuronidation Reactions

Martin Perreault, Ewa Wunsch, Andrzej Białek, +6

Canadian Journal of Gastroenterology and Hepatology

Induction of endoplasmic reticulum stress by aminosteroid derivative RM-581 leads to tumor regression in PANC-1 xenograft model

Martin Perreault, René Maltais, Jenny Roy, +4

Investigational New Drugs

Tumor BiologyAminosteroid Derivative Rm-581Cell DeathEndoplasmic Reticulum StressTumor Suppressor +7

Impact of structural modifications at positions 13, 16 and 17 of 16β-(m-carbamoylbenzyl)-estradiol on 17β-hydroxysteroid dehydrogenase type 1 inhibition and estrogenic activity

René Maltais, Alexandre Trottier, Xavier Barbeau, +5

The Journal of Steroid Biochemistry and Molecular Biology

Estrogenic ActivityPositions 13BiochemistryMedicineHormonal Receptor +5

Explorative study on the anticancer activity, selectivity and metabolic stability of related analogs of aminosteroid RM-133

Martin Perreault, René Maltais, Raphaël Dutour, +1

Steroids

Medicinal ChemistryRelated AnalogsMetabolic StabilityChemoprevention StrategyBiochemistry +8

Insight into the mode of action and selectivity of PBRM, a covalent steroidal inhibitor of 17β-hydroxysteroid dehydrogenase type 1

Alexandre Trottier, René Maltais, Diana Ayán, +6

Biochemical Pharmacology

Molecular PharmacologyMedicinal ChemistryBiochemistryMedicineNatural Sciences +7