H S Hwang

Role of the hMLH1 DNA mismatch repair protein in fluoropyrimidine-mediated cell death and cell cycle responses.

Mark Meyers, Mark W. Wagner, H S Hwang et al. · PubMed · 2001 · 229 citations

Cell Cycle Responses, Apoptosis, Mmr Deficiencies +18

Radiosensitivity of thymidylate synthase-deficient human tumor cells is affected by progression through the G1 restriction point into S-phase: implications for fluoropyrimidine radiosensitization.

H S Hwang, Thomas W. Davis, Janet A. Houghton et al. · PubMed · 2000 · 41 citations

Radiation Effect, Radiation Exposure, Cell Death +17

Selective radiosensitization of drug-resistant MutS homologue-2 (MSH2) mismatch repair-deficient cells by halogenated thymidine (dThd) analogues: Msh2 mediates dThd analogue DNA levels and the differential cytotoxicity and cell cycle effects of the dThd analogues and 6-thioguanine.

S E Berry, Thomas W. Davis, Jane E. Schupp et al. · PubMed · 2000 · 41 citations

Genome Instability, Drug-resistant Muts Homologue-2, Oncogenic Agent +14

Preclinical study of the systemic toxicity and pharmacokinetics of 5-iodo-2-deoxypyrimidinone-2'-deoxyribose as a radiosensitizing prodrug in two, non-rodent animal species: implications for phase I study design.

T J Kinsella, Jane E. Schupp, Thomas W. Davis et al. · PubMed · 2000 · 25 citations

Non-rodent Animal Species, High Ipdr, Pharmacological Study +15