Mohamed A. Shehata

GHB analogs confer neuroprotection through specific interaction with the CaMKIIα hub domain

Ulrike Leurs, Anders B. Klein, Ethan D. McSpadden et al. · Proceedings of the National Academy of Sciences · 2021 · 52 citations · Full text

The orphan G protein-coupled receptor GPR139 is activated by the peptides: Adrenocorticotropic hormone (ACTH), α-, and β-melanocyte stimulating hormone (α-MSH, and β-MSH), and the conserved core motif HFRW

Anne Cathrine Nøhr, Mohamed A. Shehata, Alexander S. Hauser et al. · Neurochemistry International · 2016 · 42 citations · Full text

The GPR139 reference agonists 1a and 7c, and tryptophan and phenylalanine share a common binding site

Anne Cathrine Nøhr, Willem Jespers, Mohamed A. Shehata et al. · Scientific Reports · 2017 · 32 citations · Full text

Novel Agonist Bioisosteres and Common Structure-Activity Relationships for The Orphan G Protein-Coupled Receptor GPR139

Mohamed A. Shehata, Anne Cathrine Nøhr, Delphine Lissa et al. · Scientific Reports · 2016 · 28 citations · Full text

Exploring the NCS-382 Scaffold for CaMKIIα Modulation: Synthesis, Biochemical Pharmacology, and Biophysical Characterization of Ph-HTBA as a Novel High-Affinity Brain-Penetrant Stabilizer of the CaMKIIα Hub Domain

Yongsong Tian, Mohamed A. Shehata, Stine Juul Gauger et al. · Journal of Medicinal Chemistry · 2022 · 14 citations · Full text