Daniel R. Southworth

An ultrapotent synthetic nanobody neutralizes SARS-CoV-2 by stabilizing inactive Spike

Michael Schoof, Bryan Faust, Reuben A. Saunders et al. · Science · 2020 · 462 citations · Full text

Materials Science, Trivalent Nanobody, Spike Protein +10

Structural Analysis of E. coli hsp90 Reveals Dramatic Nucleotide-Dependent Conformational Rearrangements

Andrew K. Shiau, Seth F. Harris, Daniel R. Southworth et al. · Cell · 2006 · 455 citations · Full text

Engineering, Structural Bioinformatics, Biomolecular Structure Prediction +8

Glucocorticoid Receptor Function Regulated by Coordinated Action of the Hsp90 and Hsp70 Chaperone Cycles

Elaine Kirschke, Devrishi Goswami, Daniel R. Southworth et al. · Cell · 2014 · 407 citations · Full text

Molecular Physiology, Signal Transduction, Hsp70 Chaperone Cycles +10

Ratchet-like polypeptide translocation mechanism of the AAA+ disaggregase Hsp104

Stephanie N. Gates, Adam L. Yokom, JiaBei Lin et al. · Science · 2017 · 271 citations · Full text

Species-Dependent Ensembles of Conserved Conformational States Define the Hsp90 Chaperone ATPase Cycle

Daniel R. Southworth, David A. Agard · Molecular Cell · 2008 · 226 citations · Full text

Cellular Enzymology, Protein Assembly, Biochemistry +10