Induction of Morphological and Biochemical Apoptosis following Prolonged Mitotic Blockage by Halichondrin B Macrocyclic Ketone Analog E7389

Galina Kuznetsov, Murray J. Towle, Hongsheng Cheng, +6

Cancer Research

In vitro and in vivo anticancer activities of synthetic (-)-laulimalide, a marine natural product microtubule stabilizing agent.

Junke Liu, Murray J. Towle, Hongsheng Cheng, +13

PubMed

Vivo Anticancer ActivitiesMedicinal ChemistryPharmaceutical ScienceMarine SpongesPolymer-drug Conjugate +11

Tubulin-based antimitotic mechanism of E7974, a novel analogue of the marine sponge natural product hemiasterlin

Galina Kuznetsov, Karen TenDyke, Murray J. Towle, +15

Molecular Cancer Therapeutics

Purified TubulinApoptosisCell DeathCytoskeletonChemical Biology +15

Novel synthetic LPS receptor agonists boost systemic and mucosal antibody responses in mice

Melinda Przetak, Jesse C. Chow, Hongsheng Cheng, +3

Vaccine

Autoimmune DiseaseMedicineImmunologyImmune RegulationAutoimmunity +6

Small molecule schweinfurthins selectively inhibit cancer cell proliferation and mTOR/AKT signaling by interfering with trans-Golgi-network trafficking

Xingfeng Bao, Wanjun Zheng, Naoko Hata Sugi, +21

Cancer Biology & Therapy

Chemoprevention StrategyCancer BiologyTumor BiologySignaling PathwayReceptor Tyrosine Kinase +15

Design, Synthesis, and Biological Evaluation of Diminutive Forms of (+)-Spongistatin 1: Lessons Learned

Amos B. Smith, Christina A. Risatti, Onur Atasoylu, +5

Journal of the American Chemical Society

Combinatorial ChemistryBioorganic ChemistryMolecular BiologyChemical BiologyAbef Analogue +15

Novel second generation analogs of eribulin. Part III: Blood–brain barrier permeability and in vivo activity in a brain tumor model

Sridhar Narayan, Eric M. Carlson, Hongsheng Cheng, +16

Bioorganic & Medicinal Chemistry Letters

Neuro-oncologyDrug TargetingPart IiiBlood–brain BarrierBlood–brain Barrier Permeability +8

Novel second generation analogs of eribulin. Part I: Compounds containing a lipophilic C32 side chain overcome P-glycoprotein susceptibility

Sridhar Narayan, Eric M. Carlson, Hongsheng Cheng, +11

Bioorganic & Medicinal Chemistry Letters

Medicinal ChemistryBiochemistryG Protein-coupled ReceptorMedicineNatural Sciences +7

Novel second generation analogs of eribulin. Part II: Orally available and active against resistant tumors in vivo

Sridhar Narayan, Eric M. Carlson, Hongsheng Cheng, +16

Bioorganic & Medicinal Chemistry Letters

Tumor BiologyMedicinePharmacologyPharmacotherapyAnti-cancer Agent +9

Design, Synthesis, and Evaluation of Irciniastatin Analogues: Simplification of the Tetrahydropyran Core and the C(11) Substituents

Qi Liu, Chihui An, Karen TenDyke, +4

The Journal of Organic Chemistry