Pieter J.A. Eichhorn

NVP-BEZ235, a Dual PI3K/mTOR Inhibitor, Prevents PI3K Signaling and Inhibits the Growth of Cancer Cells with Activating PI3K Mutations

Violeta Serra, Ben Markman, Maurizio Scaltriti et al. · Cancer Research · 2008 · 796 citations · Full text

Medicine, Oncology, Pharmacology +16

PI3K inhibition results in enhanced HER signaling and acquired ERK dependency in HER2-overexpressing breast cancer

Violeta Serra, Maurizio Scaltriti, Ludmila Prudkin et al. · Oncogene · 2011 · 534 citations · Full text

Medicine, Cancer Biology, Pharmacology +17

Phosphatidylinositol 3-Kinase Hyperactivation Results in Lapatinib Resistance that Is Reversed by the mTOR/Phosphatidylinositol 3-Kinase Inhibitor NVP-BEZ235

Pieter J.A. Eichhorn, Magüi Gili, Maurizio Scaltriti et al. · Cancer Research · 2008 · 494 citations · Full text

Medicine, Oncology, Pharmacology +17

USP15 stabilizes TGF-β receptor I and promotes oncogenesis through the activation of TGF-β signaling in glioblastoma

Pieter J.A. Eichhorn, Laura Rodón, Alba Gonzàlez-Juncà et al. · Nature Medicine · 2012 · 404 citations

Life Sciences, Molecular Biology, Oncology +12

Cyclin E amplification/overexpression is a mechanism of trastuzumab resistance in HER2 ⁺ breast cancer patients

Maurizio Scaltriti, Pieter J.A. Eichhorn, Javier Cortés et al. · Proceedings of the National Academy of Sciences · 2011 · 332 citations

Medicine, Genetics, Oncology +17