Epigenetic regulator CXXC5 recruits DNA demethylase Tet2 to regulate TLR7/9-elicited IFN response in pDCs

Shixin Ma, Xiaoling Wan, Zihou Deng, +22

The Journal of Experimental Medicine

NEAT1/hsa‐mir‐98‐5p/MAPK6 axis is involved in non–small‐cell lung cancer development

Feima Wu, Qiang Mo, Xiaoling Wan, +2

Journal of Cellular Biochemistry

Tumor MicroenvironmentNsclc DiagnosisMedicineNeat1/hsa‐mir‐98‐5p/mapk6 AxisCancer Cell Biology +12

Mixed Lineage Leukemia 5 (MLL5) Protein Regulates Cell Cycle Progression and E2F1-responsive Gene Expression via Association with Host Cell Factor-1 (HCF-1)

Peipei Zhou, Zhilong Wang, Xiujie Yuan, +11

Journal of Biological Chemistry

SLC7A11 Reduces Laser-Induced Choroidal Neovascularization by Inhibiting RPE Ferroptosis and VEGF Production

Xiaohuan Zhao, Min Gao, Jian Liang, +10

Frontiers in Cell and Developmental Biology

Mixed Lineage Leukemia 5 (MLL5) Protein Stability Is Cooperatively Regulated by O-GlcNac Transferase (OGT) and Ubiquitin Specific Protease 7 (USP7)

Xiaodan Ding, Wei Jiang, Peipei Zhou, +13

PLoS ONE

Hematological MalignancySystems BiologyCell RegulationMixed LineageMedicine +13

Targeting C3b/C4b and VEGF with a bispecific fusion protein optimized for neovascular age-related macular degeneration therapy

Shiqi Yang, Tong Li, Huixun Jia, +19

Science Translational Medicine

Ocular DiseaseImmunologyCell DeathRetinal TherapiesImmunotherapy +17

MLL5 suppresses antiviral innate immune response by facilitating STUB1-mediated RIG-I degradation

Peipei Zhou, Xiaodan Ding, Xiaoling Wan, +11

Nature Communications

AAV-mediated base-editing therapy ameliorates the disease phenotypes in a mouse model of retinitis pigmentosa

Yidong Wu, Xiaoling Wan, Dongdong Zhao, +8

Nature Communications

The chromatin remodeling subunit Baf200 promotes normal hematopoiesis and inhibits leukemogenesis

Lulu Liu, Xiaoling Wan, Peipei Zhou, +14

Journal of Hematology & Oncology

METTL3-mediated m6A modification of HMGA2 mRNA promotes subretinal fibrosis and epithelial–mesenchymal transition

Yuwei Wang, Yuhong Chen, Jian Liang, +10

Journal of Molecular Cell Biology

Subretinal FibrosisOcular DiseaseSignal TransductionTissue DevelopmentOphthalmology +13