Acute postnatal ablation of <i>Hif-2</i> α results in anemia

Michaela Gruber, Cheng‐Jun Hu, Randall S. Johnson, +3

Proceedings of the National Academy of Sciences

The transcription factor HIF-1α plays a critical role in the growth factor-dependent regulation of both aerobic and anaerobic glycolysis

Julian J. Lum, Thi Bui, Michaela Gruber, +5

Genes & Development

Metabolic RemodelingOxidative StressTranscriptional RegulationGrowth Factor-dependent RegulationRedox Regulator +19

BNip3 Regulates Mitochondrial Function and Lipid Metabolism in the Liver

D.R. Glick, Wenshuo Zhang, Michelle Beaton, +7

Molecular and Cellular Biology

Mitochondrial BiologyFatty Liver DiseaseOxidative StressMetabolic SyndromeMitochondrial Structure +18

Wnt9a signaling is required for joint integrity and regulation of<i>Ihh</i>during chondrogenesis

Daniela Später, Theo P. Hill, Roderick J. O’Sullivan, +3

Development

GeneticsWnt9a SignalingSkeleton ElementsMechanotransductionMusculoskeletal Research +19

Dysregulated mTORC1 renders cells critically dependent on desaturated lipids for survival under tumor-like stress

Regina M. Young, Daniel Ackerman, Zachary L. Quinn, +8

Genes & Development

Solid TumorsTumor-like StressStress Response PathwaysCell DeathPathology +17

Growth dynamics in naturally progressing chronic lymphocytic leukaemia

Michaela Gruber, Ivana Božić, Ignaty Leshchiner, +24

Nature

Lymphoid NeoplasiaMalignant Blood DisorderHematologyImmunologyGrowth Dynamics +4

Dupilumab Treatment in Children Aged 6–11 Years With Atopic Dermatitis: A Multicentre, Real-Life Study

Maddalena Napolitano, Gabriella Fabbrocini, Iria Neri, +35

Pediatric Drugs

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Splicing modulation sensitizes chronic lymphocytic leukemia cells to venetoclax by remodeling mitochondrial apoptotic dependencies

Elisa ten Hacken, Rebecca Valentin, Fara Faye Regis, +27

JCI Insight

Hematological MalignancyLymphoid NeoplasiaBcl2 DependenceAntiapoptotic DependenciesSpliceosome Modulator +12

Overexpression of uridine diphospho glucuronosyltransferase 2B17 in high-risk chronic lymphocytic leukemia

Michaela Gruber, Judith Bellemare, Gregor Hoermann, +12

Blood

Combined chemosensitivity and chromatin profiling prioritizes drug combinations in CLL

Christian Schmidl, Gregory I. Vladimer, André F. Rendeiro, +23

Nature Chemical Biology

Systems PharmacologyChromatinDrug TargetChromatin StructureChromatin Remodeling +9