Treatment of arthritis with a selective inhibitor of c-Fos/activator protein-1

Yukihiko Aikawa, Kimiko Morimoto, Tetsuya Yamamoto, +5

Nature Biotechnology

InflammationRheumatologyRheumatoid DisorderC-fos/activator Protein-1Anti-inflammatory +8

Role of natural killer cells and TCRγ δ T cells in acute autoimmune encephalomyelitis

Yoh Matsumoto, Kuniko Kohyama, Yukihiko Aikawa, +4

European Journal of Immunology

An anti-rheumatic agent T-614 inhibits NF-κB activation in LPS- and TNF-α-stimulated THP-1 cells without interfering with IκBα degradation

Yukihiko Aikawa, Masakazu Yamamoto, Takuya Yamamoto, +2

Inflammation Research

InflammationRheumatologyAnti-inflammatoryIκbα DegradationAutoimmune Disease +10

Competitive PCR quantification of pro- and anti-inflammatory cytokine mRNA in the central nervous system during autoimmune encephalomyelitis

Naoyuki Tanuma, Takashi Kojima, Taekyun Shin, +4

Journal of Neuroimmunology

InflammationCytokineAutoimmune DiseaseMedicineImmunology +13

T-614, a Novel Antirheumatic Drug, Inhibits Both the Activity and Induction of Cyclooxygenase-2 (COX-2) in Cultured Fibroblasts

Keiichi Tanaka, Hiroki Kawasaki, Kiyonobu Kurata, +3

The Japanese Journal of Pharmacology

Pge2 ProductionLipid PeroxidationImmunologyPathologyCell Death +16

Inhibitory effect of T-614 on tumor necrosis factor-alpha induced cytokine production and nuclear factor-kappaB activation in cultured human synovial cells.

Masataka Kohno, Yukihiko Aikawa, Yasunori Tsubouchi, +7

PubMed

Pharmacological studies of the new antiinflammatory agent 3-formylamino-7-methylsulfonylamino-6-phenoxy-4H-1-benzopyran-4-o ne. 1st communication: antiinflammatory, analgesic and other related properties.

K. Tanaka, T Shimotori, Shinji Makino, +4

PubMed

Antiparasitic AgentPain MedicineImmunologyPharmacotherapyPharmaceutical Chemistry +16

A selective inhibition of c-Fos/activator protein-1 as a potential therapeutic target for intervertebral disc degeneration and associated pain

Hiroto Makino, Shoji Seki, Yasuhito Yahara, +11

Scientific Reports

A selective c-Fos/AP-1 inhibitor prevents cartilage destruction and subsequent osteophyte formation

Hiraku Motomura, Shoji Seki, Shunichi Shiozawa, +3

Biochemical and Biophysical Research Communications

Bone Morphogenic ProteinMedicineCartilage DegenerationCell DeathOsteoarthritis +7

Discovery of Nonpeptidic Small-Molecule AP-1 Inhibitors:  Lead Hopping Based on a Three-Dimensional Pharmacophore Model

Keiichi Tsuchida, Hisaaki Chaki, Tadakazu Takakura, +5

Journal of Medicinal Chemistry