R. J. Highet

Sequential oxidation and glutathione addition to 1,4-benzoquinone: correlation of toxicity with increased glutathione substitution.

S S Lau, Barbara Hill, R. J. Highet et al. · Molecular Pharmacology · 1988 · 168 citations

Pharmacy, Biochemistry, Toxicology +16

Glutathione conjugates of 2-bromohydroquinone are nephrotoxic.

Terrence J. Monks, S S Lau, R. J. Highet et al. · Drug Metabolism and Disposition · 1985 · 126 citations

Medicine, Biochemistry, Pharmacology +15

A new class of indolizidine alkaloids from the poison frog, Dendrobates tricolor. X-ray analysis of 8-hydroxy-8-methyl-6-(2'-methylhexylidene)-1-azabicyclo[4.3.0]nonane

John W. Daly, Takeshi Tokuyama, T. Fujiwara et al. · Journal of the American Chemical Society · 1980 · 108 citations

Pharmacy, Chemistry, Medicinal Chemistry +10

The formation of diglutathionyl dithiocarbonate as a metabolite of chloroform, bromotrichloromethane, and carbon tetrachloride.

L R Pohl, Richard V. Branchflower, R. J. Highet et al. · Drug Metabolism and Disposition · 1981 · 102 citations

Medicine, Biochemistry, Pharmacology +10

Alkaloids from Dendrobatid Frogs: Structures of Two ω-Hydroxy Congeners of 3-Butyl-5-Propylindolizidine and Occurrence of 2,5-Disubstituted Pyrrolidines and a 2,6-Disubstituted Piperidine

John W. Daly, Thomas F. Spande, Noel F. Whittaker et al. · Journal of Natural Products · 1986 · 94 citations

Pharmacy, Medicinal Chemistry, Pharmacology +9