Domingos J. Silva

Discovery of GSK1070916, a Potent and Selective Inhibitor of Aurora B/C Kinase

Nicholas D. Adams, Jerry L. Adams, Joelle L. Burgess et al. · Journal of Medicinal Chemistry · 2010 · 111 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +14

Stereospecific Solution- and Solid-Phase Glycosylations. Synthesis of β-Linked Saccharides and Construction of Disaccharide Libraries Using Phenylsulfenyl 2-Deoxy-2-Trifluoroacetamido Glycopyranosides as Glycosyl Donors¹

Domingos J. Silva, Hui‐Ming Wang, Nigel M. Allanson et al. · The Journal of Organic Chemistry · 1999 · 86 citations

Life Sciences, Biochemistry, Carbohydrate Biochemistry +14

Discovery of Novel Disaccharide Antibacterial Agents Using a Combinatorial Library Approach

Michael J. Sofia, Nigel M. Allanson, Nicole T. Hatzenbuhler et al. · Journal of Medicinal Chemistry · 1999 · 66 citations

Pharmacy, Medicinal Chemistry, Pharmacology +13

Inactivation of Ribonucleotide Reductase by (<i>E</i>)-2‘-Fluoromethylene-2‘-deoxycytidine 5‘-Diphosphate:  A Paradigm for Nucleotide Mechanism-Based Inhibitors

Wilfred A. van der Donk, Guixue Yu, Domingos J. Silva et al. · Biochemistry · 1996 · 64 citations

Life Sciences, Biochemistry, Molecular Biology +15

Gemcitabine 5‘-Triphosphate Is a Stoichiometric Mechanism-Based Inhibitor of <i>Lactobacillus leichmannii</i> Ribonucleoside Triphosphate Reductase:  Evidence for Thiyl Radical-Mediated Nucleotide Radical Formation

Domingos J. Silva, JoAnne Stubbe, Vicente Sámano et al. · Biochemistry · 1998 · 26 citations

Life Sciences, Biochemistry, Microbiology +17