Jeffrey T. Mihalic

Discovery of AMG 925, a FLT3 and CDK4 Dual Kinase Inhibitor with Preferential Affinity for the Activated State of FLT3

Zhihong Li, Xianghong Wang, John Eksterowicz et al. · Journal of Medicinal Chemistry · 2014 · 70 citations · Full text

Molecular Biology, Structural Optimization, Activated State +22

Optimization of the heterocyclic core of the quinazolinone-derived CXCR3 antagonists

An‐Rong Li, Michael G. Johnson, Jiwen Liu et al. · Bioorganic & Medicinal Chemistry Letters · 2007 · 43 citations · Full text

Combinatorial Chemistry, Medicinal Chemistry, Heterocyclic +8

Design and optimization of imidazole derivatives as potent CXCR3 antagonists

Xiaohui Du, Xiaoqi Chen, Jeffrey T. Mihalic et al. · Bioorganic & Medicinal Chemistry Letters · 2007 · 33 citations · Full text

Imidazole Derivatives, Combinatorial Chemistry, Medicinal Chemistry +8

Design, Synthesis, and Biological Evaluation of Homologous Phosphonic Acids and Sulfonic Acids as Inhibitors of Lumazine Synthase

Mark Cushman, Jeffrey T. Mihalic, Klaus Kis et al. · The Journal of Organic Chemistry · 1999 · 27 citations

Organic Chemistry, Sulfonic Acids, Chemical Biology +19

Incorporation of an Amide into 5-Phosphonoalkyl-6-<scp>d</scp>-ribitylaminopyrimidinedione Lumazine Synthase Inhibitors Results in an Unexpected Reversal of Selectivity for Riboflavin Synthase vs Lumazine Synthase

Mark Cushman, Donglaï Yang, Jeffrey T. Mihalic et al. · The Journal of Organic Chemistry · 2002 · 23 citations