D. Needle

Structures of the<i>Middle East respiratory syndrome coronavirus</i>3C-like protease reveal insights into substrate specificity

D. Needle, G.T. Lountos, David S. Waugh · Acta Crystallographica Section D Biological Crystallography · 2015 · 105 citations · Full text

Viral Replication, Viral Pathogenesis, Molecular Biology +16

Hyperthermia-triggered intracellular delivery of anticancer agent to HER2+ cells by HER2-specific affibody (ZHER2-GS-Cys)-conjugated thermosensitive liposomes (HER2+ affisomes)

Brandon Smith, Ilya Lyakhov, Kristin H. Loomis et al. · Journal of Controlled Release · 2011 · 84 citations

Her2-specific Affibody, Nanomedicine, Cell-based Drug Delivery +9

Sequence of the <i>Escherichia coli</i> O121 O-Antigen Gene Cluster and Detection of Enterohemorrhagic <i>E. coli</i> O121 by PCR Amplification of the <i>wzx</i> and <i>wzy</i> Genes

Pina M. Fratamico, Connie Briggs, D. Needle et al. · Journal of Clinical Microbiology · 2003 · 74 citations · Full text

Pcr Amplification, Pathogen Detection, Escherichia Coli O121 +15

Identification of a ligand binding hot spot and structural motifs replicating aspects of tyrosyl-DNA phosphodiesterase I (TDP1) phosphoryl recognition by crystallographic fragment cocktail screening

G.T. Lountos, Xue Zhi Zhao, Evgeny Kiselev et al. · Nucleic Acids Research · 2019 · 38 citations · Full text

Drug Target, Protein Assembly, Abstract Tyrosyl Dna-phosphodiesterase +25

Small molecule microarray identifies inhibitors of tyrosyl-DNA phosphodiesterase 1 that simultaneously access the catalytic pocket and two substrate binding sites

Xue Zhi Zhao, Evgeny Kiselev, G.T. Lountos et al. · Chemical Science · 2021 · 33 citations · Full text