Concepedia

R. Brundiers

RB

8

Publications

436

Citations

8

H-Index

1998

Active since

Affiliations

Max Planck Institute for Biophysical Chemistry(Current)

Max Planck Society

Max Planck Institute of Molecular Physiology

Max Planck Institute for Medical Research

MorphoSys (Germany)

R. Brundiers is an author at Max Planck Institute for Biophysical Chemistry specializing in signal transduction, medicine, and cell signaling.

Top concepts

Publications per year

1998–2008

8

Publications

8

Insights into the phosphoryltransfer mechanism of human thymidylate kinase gained from crystal structures of enzyme complexes along the reaction coordinate

Nils Ostermann, Ilme Schlichting, R. Brundiers et al. · Structure · 2000 · 105 citations · Full text

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Structural basis for efficient phosphorylation of 3′-azidothymidine monophosphate by <i>Escherichia coli</i> thymidylate kinase

Arnon Lavie, Nils Ostermann, R. Brundiers et al. · Proceedings of the National Academy of Sciences · 1998 · 90 citations · Full text

Crystal Structure of Yeast Thymidylate Kinase Complexed with the Bisubstrate Inhibitor <i>P</i><sup>1</sup>-(5‘-Adenosyl) <i>P</i><sup>5</sup>-(5‘-Thymidyl) Pentaphosphate (TP<sub>5</sub>A) at 2.0 Å Resolution:  Implications for Catalysis and AZT Activation<sup>,</sup>

Arnon Lavie, Manfred Konrad, R. Brundiers et al. · Biochemistry · 1998 · 70 citations

Modifying Human Thymidylate Kinase to Potentiate Azidothymidine Activation

R. Brundiers, Arnon Lavie, T. Veit et al. · Journal of Biological Chemistry · 1999 · 63 citations · Full text

Potentiating AZT activation: structures of wild-type and mutant human thymidylate kinase suggest reasons for the mutants’ improved kinetics with the HIV prodrug metabolite AZTMP 1 1Edited by J. Karn

Nils Ostermann, Arnon Lavie, S. Padiyar et al. · Journal of Molecular Biology · 2000 · 52 citations

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