Adrian Kotey

Back Pocket Flexibility Provides Group II p21-Activated Kinase (PAK) Selectivity for Type I 1/2 Kinase Inhibitors

Steven T. Staben, Jianwen A. Feng, Karen S. Lyle et al. · Journal of Medicinal Chemistry · 2014 · 65 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17

Imaging Mutant Huntingtin Aggregates: Development of a Potential PET Ligand

Longbin Liu, Michael E. Prime, Matt R. Lee et al. · Journal of Medicinal Chemistry · 2020 · 56 citations

Medicine, Neuroscience, Nuclear Medicine +17

An orally bioavailable positive allosteric modulator of the mGlu4 receptor with efficacy in an animal model of motor dysfunction

Stephen P. East, Samantha J. Bamford, Matthias G. A. Dietz et al. · Bioorganic & Medicinal Chemistry Letters · 2010 · 46 citations · Full text

Medicine, Neuroscience, Pharmacology +11

Synthesis, SAR, and Series Evolution of Novel Oxadiazole-Containing 5-Lipoxygenase Activating Protein Inhibitors: Discovery of 2-[4-(3-{(<i>R</i>)-1-[4-(2-Amino-pyrimidin-5-yl)-phenyl]-1-cyclopropyl-ethyl}-[1,2,4]oxadiazol-5-yl)-pyrazol-1-yl]-<i>N</i>,<i>N</i>-dimethyl-acetamide (BI 665915)

Hidenori Takahashi, Doris Riether, Alessandra Bartolozzi et al. · Journal of Medicinal Chemistry · 2015 · 36 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17

[¹¹C]CHDI-626, a PET Tracer Candidate for Imaging Mutant Huntingtin Aggregates with Reduced Binding to AD Pathological Proteins

Longbin Liu, Peter Johnson, Michael E. Prime et al. · Journal of Medicinal Chemistry · 2021 · 31 citations

Life Sciences, Neurology, Neuroscience +17