Exaggerated false positives by popular differential expression methods when analyzing human population samples

Yumei Li, Xinzhou Ge, Fanglue Peng, +2

Genome biology

An atlas of alternative polyadenylation quantitative trait loci contributing to complex trait and disease heritability

Lei Li, Kai-Lieh Huang, Yipeng Gao, +10

Nature Genetics

Complex Trait GeneticsQuantitative GeneticsGenetic DeterminantGenotype-phenotype AssociationDisease Heritability +8

Adaptive endoplasmic reticulum stress signalling via IRE1α–XBP1 preserves self-renewal of haematopoietic and pre-leukaemic stem cells

Lu Liu, Meiling Zhao, Xi Jin, +8

Nature Cell Biology

Transcriptional RegulationDevelopmental BiologySignaling PathwayCell RegulationMolecular Regulation +6

Modulation of the proteostasis network promotes tumor resistance to oncogenic KRAS inhibitors

Xiangdong Lv, Xuan Lu, Jin Cao, +36

Science

DORGE: Discovery of Oncogenes and tumoR suppressor genes using Genetic and Epigenetic features

Jie Lyu, Jingyi Jessica Li, Jianzhong Su, +4

Science Advances

Epigenetic ChangeGeneticsGene CharacterizationMolecular GeneticsEpigenetics +15

Protein quality control through endoplasmic reticulum-associated degradation maintains haematopoietic stem cell identity and niche interactions

Longyong Xu, Xia Liu, Fanglue Peng, +24

Nature Cell Biology

Protein Quality ControlSystems BiologyCell RegulationEndoplasmic Reticulum-associated DegradationEndocytic Pathway +7

Alternative polyadenylation transcriptome-wide association study identifies APA-linked susceptibility genes in brain disorders

Ya Cui, Frederick J. Arnold, Fanglue Peng, +6

Nature Communications

IRE1α silences dsRNA to prevent taxane-induced pyroptosis in triple-negative breast cancer

Longyong Xu, Fanglue Peng, Qin Luo, +44

Cell

Tumor BiologyBreast OncologyMedicineCancer Cell BiologyBreast Cancer +9

Notch-induced endoplasmic reticulum-associated degradation governs mouse thymocyte β−selection

Xia Liu, Jingjing Yu, Longyong Xu, +11

eLife

3′aQTL-atlas: an atlas of 3′UTR alternative polyadenylation quantitative trait loci across human normal tissues

Ya Cui, Fanglue Peng, Dan Wang, +4

Nucleic Acids Research

Human Normal TissuesGeneticsHuman PolymorphismGene CharacterizationMolecular Genetics +23