Samantha Jane Hughes

Design, Synthesis, and Biological Evaluation of Potent and Selective Class IIa Histone Deacetylase (HDAC) Inhibitors as a Potential Therapy for Huntington’s Disease

Roland W. Bürli, Christopher A. Luckhurst, Omar Aziz et al. · Journal of Medicinal Chemistry · 2013 · 147 citations · Full text

Aldo-keto Reductase, Molecular Biology, Chemical Biology +19

Discovery of AZD9833, a Potent and Orally Bioavailable Selective Estrogen Receptor Degrader and Antagonist

James S. Scott, Amber Balazs, Bernard Barlaam et al. · Journal of Medicinal Chemistry · 2020 · 109 citations · Full text

Design and Synthesis of Inhaled p38 Inhibitors for the Treatment of Chronic Obstructive Pulmonary Disease

David S. Millan, Mark E. Bunnage, Jane L. Burrows et al. · Journal of Medicinal Chemistry · 2011 · 94 citations · Full text

Pharmaceutical Science, P38 Inhibitors, Pharmacotherapy +16

Tools for bioindicator assessment in rivers: The importance of spatial scale, land use patterns and biotic integration

Rui Cortes, Samantha Jane Hughes, Vítor Pereira et al. · Ecological Indicators · 2013 · 71 citations

River Basin Management, Engineering, Land Use Patterns +7

Design of a multi-purpose fragment screening library using molecular complexity and orthogonal diversity metrics

Wan F. Lau, Jane M. Withka, David Hepworth et al. · Journal of Computer-Aided Molecular Design · 2011 · 61 citations

Targeted Library, Molecular Characterization, Biochemistry +13