The Bile Acid Chenodeoxycholic Acid Increases Human Brown Adipose Tissue Activity

Evie P. M. Broeders, Emmani B. M. Nascimento, Bas Havekes, +12

Cell Metabolism

ObesityMetabolic SyndromeBiochemistryLipid NutritionMedicine +9

Hypothalamic bile acid-TGR5 signaling protects from obesity

Ashley Castellanos-Jankiewicz, Omar Guzmán‐Quevedo, Valérie S. Fénelon, +30

Cell Metabolism

ObesityMetabolic SyndromeEnergy HomeostasisLiver PhysiologyPhysiology +8

Hydroxamates: Relationships between Structure and Plasma Stability

Marion Flipo, Julie Charton, Akila Hocine, +3

Journal of Medicinal Chemistry

The Ebola virus ribonucleoprotein complex: A novel VP30–L interaction identified

Allison Groseth, Julie Charton, Markus Sauerborn, +4

Virus Research

Virus StructureViral ReplicationMolecular VirologyPathogenesisMolecular Biology +5

Catalytic site inhibition of insulin-degrading enzyme by a small molecule induces glucose intolerance in mice

Rebecca Deprez‐Poulain, Nathalie Hennuyer, Damien Bosc, +27

Nature Communications

Synthesis and biological evaluation of benzimidazole derivatives as potent AMP-activated protein kinase activators

Julie Charton, Sophie Girault‐Mizzi, Marie‐Ange Debreu‐Fontaine, +5

Bioorganic & Medicinal Chemistry

Drug TargetBiochemistryBenzimidazole DerivativesMedicineNatural Sciences +6

Drug to Genome to Drug: Discovery of New Antiplasmodial Compounds

Terence Beghyn, Julie Charton, Florence Leroux, +5

Journal of Medicinal Chemistry

Topical Intestinal Aminoimidazole Agonists of G-Protein-Coupled Bile Acid Receptor 1 Promote Glucagon Like Peptide-1 Secretion and Improve Glucose Tolerance

Manuel Lasalle, Vanessa Hoguet, Nathalie Hennuyer, +16

Journal of Medicinal Chemistry

Promote GlucagonImmunologyGastroenterologyGlucose HomeostasisDigestive Tract +16

NMR Spectroscopy of the Main Protease of SARS‐CoV‐2 and Fragment‐Based Screening Identify Three Protein Hotspots and an Antiviral Fragment

François‐Xavier Cantrelle, Emmanuelle Boll, Lucile Brier, +10

Angewandte Chemie International Edition

Conversion of Sterically Hindered Diacylated 1,2-Phenylenediamines into 2-Substituted Benzimidazoles

Julie Charton, Sophie Girault‐Mizzi, Christian Sergheraert

Chemical and Pharmaceutical Bulletin

Sterically HinderedCombinatorial ChemistryMedicinal ChemistryHeterocyclicBiochemistry +11