David A. Parfitt

Identification and Correction of Mechanisms Underlying Inherited Blindness in Human iPSC-Derived Optic Cups

David A. Parfitt, Amelia Lane, Conor M. Ramsden et al. · Cell stem cell · 2016 · 297 citations · Full text

Do all trees carry the seeds of their own destruction? PCR reveals numerous wood decay fungi latently present in sapwood of a wide range of angiosperm trees

David A. Parfitt, Julie Hunt, David H. Dockrell et al. · Fungal ecology · 2010 · 222 citations

Biology, Numerous Wood Decay, Own Destruction +8

The ataxia protein sacsin is a functional co-chaperone that protects against polyglutamine-expanded ataxin-1

David A. Parfitt, Gregory J. Michael, Esmeralda G. M. Vermeulen et al. · Human Molecular Genetics · 2009 · 192 citations · Full text

Mitochondrial dysfunction and Purkinje cell loss in autosomal recessive spastic ataxia of Charlevoix-Saguenay (ARSACS)

Martine Girard, Roxanne Larivière, David A. Parfitt et al. · Proceedings of the National Academy of Sciences · 2012 · 191 citations

Pyramidal Spasticity, Neurodegenerative Diseases, Sacsin Knockout Mice +14

Splice-Modulating Oligonucleotide QR-110 Restores CEP290 mRNA and Function in Human c.2991+1655A>G LCA10 Models

Kalyan Dulla, Mònica Aguilà, Amelia Lane et al. · Molecular Therapy — Nucleic Acids · 2018 · 162 citations · Full text

G Lca10 Models, Transcriptional Regulation, Natural Sciences +8