ULBPs, Novel MHC Class I–Related Molecules, Bind to CMV Glycoprotein UL16 and Stimulate NK Cytotoxicity through the NKG2D Receptor

David Cosman, Jürgen Müllberg, Claire L. Sutherland, +5

Immunity

Nkg2d ReceptorStimulate Nk CytotoxicityViral ImmunityImmunologyCell Death +7

The human T cell antigen gp39, a member of the TNF gene family, is a ligand for the CD40 receptor: expression of a soluble form of gp39 with B cell co-stimulatory activity.

Diane Hollenbaugh, Laura S. Grosmaire, C.D. Kullas, +6

The EMBO Journal

Autoimmune DiseaseSoluble FormAdaptive Immune SystemT-regulatory CellImmunology +10

Human Cytomegalovirus Glycoprotein UL16 Causes Intracellular Sequestration of NKG2D Ligands, Protecting Against Natural Killer Cell Cytotoxicity

Claire Dunn, N. Jan Chalupny, Claire L. Sutherland, +4

The Journal of Experimental Medicine

UL16-Binding Proteins, Novel MHC Class I-Related Proteins, Bind to NKG2D and Activate Multiple Signaling Pathways in Primary NK Cells

Claire L. Sutherland, N. Jan Chalupny, Kenneth Schooley, +3

The Journal of Immunology

ImmunologyCell DeathImmunologic MechanismUlbp ExpressionPrimary Nk Cells +17

ULBP4 is a novel ligand for human NKG2D

N. Jan Chalupny, Claire L. Sutherland, W Lawrence, +2

Biochemical and Biophysical Research Communications

Molecular ImmunologyImmunologyHuman Nkg2dMedicineCell Biology +2

Down-regulation of the NKG2D ligand MICA by the human cytomegalovirus glycoprotein UL142

N. Jan Chalupny, Annie Rein‐Weston, Stephanie Dosch, +1

Biochemical and Biophysical Research Communications

Viral PathogenesisImmunologyAntiviral ResponseVirologyViral Structural Protein +4

Intracellular Retention of the MHC Class I-Related Chain B Ligand of NKG2D by the Human Cytomegalovirus UL16 Glycoprotein

Jennifer D. Wu, N. Jan Chalupny, Thomas Manley, +3

The Journal of Immunology

ImmunologyImmunologic MechanismAntigen ProcessingImmunotherapyViral Persistence +15

Cell Surface Organization of Stress-inducible Proteins ULBP and MICA That Stimulate Human NK Cells and T Cells via NKG2D

Konstantina Eleme, Sabrina B. Taner, Björn Önfelt, +7

The Journal of Experimental Medicine

ULBPs, human ligands of the NKG2D receptor, stimulate tumor immunity with enhancement by IL-15

Claire L. Sutherland, Brian Rabinovich, N. Jan Chalupny, +3

Blood

Tyrosine phosphorylation of CD19 in pre-B and mature B cells.

N. Jan Chalupny, Steven B. Kanner, Gary L. Schieven, +4

The EMBO Journal

Signal TransductionMature B CellsLymphocyte DevelopmentAdaptive Immune SystemReceptor Tyrosine Kinase +6