Lack of beta-arrestin signaling in the absence of active G proteins

Manuel Grundmann, Nicole Merten, Davide Malfacini, +21

Nature Communications

The experimental power of FR900359 to study Gq-regulated biological processes

Ramona Schrage, Anna-Lena Schmitz, Evelyn Gaffal, +43

Nature Communications

Deconvolution of complex G protein–coupled receptor signaling in live cells using dynamic mass redistribution measurements

R Schröder, Nicole Janssen, Johannes Schmidt, +14

Nature Biotechnology

Live CellsMolecular PhysiologySignal TransductionG Protein-coupled ReceptorMedicine +10

Applying label-free dynamic mass redistribution technology to frame signaling of G protein–coupled receptors noninvasively in living cells

R Schröder, Johannes Schmidt, Stefanie Blättermann, +11

Nature Protocols

Signal TransductionMolecular PhysiologySignaling PathwayG Protein-coupled ReceptorMedicine +9

Decoding Signaling and Function of the Orphan G Protein–Coupled Receptor GPR17 with a Small-Molecule Agonist

Stephanie Hennen, Haibo Wang, Lucas Peters, +20

Science Signaling

Molecular BiologySmall-molecule AgonistSynaptic SignalingCellular PhysiologySocial Sciences +20

The allosteric vestibule of a seven transmembrane helical receptor controls G-protein coupling

Andreas Böck, Nicole Merten, Ramona Schrage, +16

Nature Communications

Discovery of Potent and Selective Agonists for the Free Fatty Acid Receptor 1 (FFA₁/GPR40), a Potential Target for the Treatment of Type II Diabetes

Elisabeth Christiansen, Christian Urban, Nicole Merten, +10

Journal of Medicinal Chemistry

Heterotrimeric G Protein Subunit Gαq Is a Master Switch for Gβγ-Mediated Calcium Mobilization by Gi-Coupled GPCRs

Eva Marie Pfeil, Julian Brands, Nicole Merten, +26

Molecular Cell

Signal TransductionMolecular PhysiologyBiochemistryG Protein-coupled ReceptorCell Signaling +9

Receptor Subtype-specific Docking of Asp6.59 with C-terminal Arginine Residues in Y Receptor Ligands

Nicole Merten, Diana Lindner, Nadine Rabe, +4

Journal of Biological Chemistry

Molecular BiologyBind Neuropeptide YY ReceptorsProteomicsBiochemistry +16

The Orphan G Protein-coupled Receptor GPR17 Negatively Regulates Oligodendrocyte Differentiation via Gαi/o and Its Downstream Effector Molecules

Katharina Simon, Stephanie Hennen, Nicole Merten, +4

Journal of Biological Chemistry