Yutaro Otsuka

ARF6 and AMAP1 are major targets of <i>KRAS</i> and <i>TP53</i> mutations to promote invasion, PD-L1 dynamics, and immune evasion of pancreatic cancer

Shigeru Hashimoto, Shotaro Furukawa, Ari Hashimoto et al. · Proceedings of the National Academy of Sciences · 2019 · 161 citations · Full text

Medicine, Cancer Biology, Oncology +16

P53- and mevalonate pathway–driven malignancies require Arf6 for metastasis and drug resistance

Ari Hashimoto, Tsukasa Oikawa, Shigeru Hashimoto et al. · The Journal of Cell Biology · 2016 · 58 citations · Full text

Medicine, Cancer Biology, Oncology +17

Engagement of Overexpressed Her2 with GEP100 Induces Autonomous Invasive Activities and Provides a Biomarker for Metastases of Lung Adenocarcinoma

Toshi Menju, Shigeru Hashimoto, Ari Hashimoto et al. · PLoS ONE · 2011 · 45 citations · Full text

Medicine, Molecular Biology, Oncology +16

Frequent overexpression of AMAP1, an Arf6 effector in cell invasion, is characteristic of the MMTV-PyMT rather than the MMTV-Neu human breast cancer model

Yutaro Otsuka, Tsukasa Oikawa, Hinako Yoshino et al. · Cell Communication and Signaling · 2018 · 44 citations · Full text

Medicine, Cancer Biology, Oncology +17

Acquired platinum resistance involves epithelial to mesenchymal transition through ubiquitin ligase FBXO32 dysregulation

Nobuyuki Tanaka, Takeo Kosaka, Yasumasa Miyazaki et al. · JCI Insight · 2016 · 26 citations · Full text

Medicine, Molecular Biology, Oncology +17