Translocator Protein (18 kD) as Target for Anxiolytics Without Benzodiazepine-Like Side Effects

Rainer Rupprecht, Gerhard Rammes, Daniela Eser, +17

Science

Drug TargetBiochemistryTranslocator ProteinMedicinePsychotropic Medication +12

Anxiolytic-Like Effects of the Prototypical Metabotropic Glutamate Receptor 5 Antagonist 2-Methyl-6-(phenylethynyl)pyridine in Rodents

Will Spooren, A. Vassout, H.C. Neijt, +3

Journal of Pharmacology and Experimental Therapeutics

Locomotor activity, defecation score and corticosterone levels during an openfield exposure: A comparison among individually and group-housed rats, and genetically selected rat lines

C. Gentsch, M. Lichtsteiner, H. Feer

Physiology & Behavior

Openfield ExposureBehavioral NeuroscienceNeurophysiologyNeuroanatomyPhysiology +11

Behavioral Characterization of the Novel GABAB Receptor-Positive Modulator GS39783 (N,N′-Dicyclopentyl-2-methylsulfanyl-5-nitro-pyrimidine-4,6-diamine): Anxiolytic-Like Activity without Side Effects Associated with Baclofen or Benzodiazepines

John F. Cryan, Peter H. Kelly, Frédérique Chaperon, +7

Journal of Pharmacology and Experimental Therapeutics

Phosphinic Acid Analogs of GABA. 1. New Potent and Selective GABAB Agonists

Wolfgang Froestl, Stuart J. Mickel, Roger G. Hall, +6

Journal of Medicinal Chemistry

Novel Gabab AntagonistsPharmacotherapyPharmaceutical ChemistryMolecular PharmacologyMedicinal Chemistry +14

Differential hormonal and physiological responses to stress in Roman high- and low-avoidance rats

C. Gentsch, M. Lichtsteiner, Peter Driscoll, +1

Physiology & Behavior

Stress HormoneBehavioral NeuroscienceStressPhysiologyNeuroendocrine Mechanism +12

Pharmacological and endocrinological characterisation of stress-induced hyperthermia in singly housed mice using classical and candidate anxiolytics (LY314582, MPEP and NKP608)

Will Spooren, Philippe Schoeffter, F. Gasparini, +2

European Journal of Pharmacology

InflammationMolecular PharmacologyHyperthermiaStress HormoneMedicine +9

Open field and elevated plus-maze: A behavioural comparison between spontaneously hypertensive (SHR) and Wistar-Kyoto (WKY) rats and the effects of chlordiazepoxide

C. Gentsch, M. Lichtsteiner, H. Feer

Behavioural Brain Research

Behavioural ComparisonHypertensionOpen FieldBlood PressureNeurophysiology +9

Isolation-induced locomotor hyperactivity and hypoalgesia in rats are prevented by handling and reversed by resocialization

C. Gentsch, M. Lichtsteiner, H.R. Frischknecht, +2

Physiology & Behavior

Behavioral NeuroscienceNeuroanatomyNeurophysiologyPhysiologyNeuroendocrine Mechanism +9

The selective nicotinic acetylcholine receptor α7 agonist JN403 is active in animal models of cognition, sensory gating, epilepsy and pain

Dominik Feuerbach, Kurt Lingenhoehl, Hans-Rudolf Olpe, +8

Neuropharmacology

Synaptic TransmissionNeurotransmitterSynaptic SignalingSocial SciencesNicotine +14