Alessandro Poffe

Discovery process and pharmacological characterization of a novel dual orexin 1 and orexin 2 receptor antagonist useful for treatment of sleep disorders

Romano Di Fabio, Annalisa Pellacani, Stefania Faedo et al. · Bioorganic & Medicinal Chemistry Letters · 2011 · 51 citations · Full text

Sleep Disorders, Sleep, Sleep Disorder +10

GSK356278, a Potent, Selective, Brain-Penetrant Phosphodiesterase 4 Inhibitor That Demonstrates Anxiolytic and Cognition-Enhancing Effects without Inducing Side Effects in Preclinical Species

A. Richard Rutter, Alessandro Poffe, Palmina Cavallini et al. · Journal of Pharmacology and Experimental Therapeutics · 2014 · 49 citations

Characterisation of the selective 5-HT1B receptor antagonist SB-616234-A (1-[6-(cis-3,5-dimethylpiperazin-1-yl)-2,3-dihydro-5-methoxyindol-1-yl]-1-[2′-methyl-4′-(5-methyl-1,2,4-oxadiazol-3-yl)biphenyl-4-yl]methanone hydrochloride): In vivo neurochemical and behavioural evidence of anxiolytic/antidepressant activity

Lee A. Dawson, Zoë A. Hughes, Kathryn R. Starr et al. · Neuropharmacology · 2006 · 40 citations

Psychotropic Medication, Psychopharmacology, Pharmacotherapy +19

Identification, biological characterization and pharmacophoric analysis of a new potent and selective NK1 receptor antagonist clinical candidate

Romano Di Fabio, Giuseppe Alvaro, Simone Braggio et al. · Bioorganic & Medicinal Chemistry · 2013 · 25 citations · Full text

Biological Characterization, Novel Therapy, Functional Selectivity +9