Antibody-drug conjugates with dual payloads for combating breast tumor heterogeneity and drug resistance

Chisato M. Yamazaki, Aiko Yamaguchi, Yasuaki Anami, +7

Nature Communications

Glutamic acid–valine–citrulline linkers ensure stability and efficacy of antibody–drug conjugates in mice

Yasuaki Anami, Chisato M. Yamazaki, Wei Xiong, +4

Nature Communications

Disrupting LILRB4/APOE Interaction by an Efficacious Humanized Antibody Reverses T-cell Suppression and Blocks AML Development

Xun Gui, Mi Deng, Hao Song, +23

Cancer Immunology Research

Enzymatic conjugation using branched linkers for constructing homogeneous antibody–drug conjugates with high potency

Yasuaki Anami, Wei Xiong, Xun Gui, +5

Organic & Biomolecular Chemistry

Homogeneous Antibody–drug ConjugatesImmunotherapySynthetic ImmunologyBranched LinkersMedicinal Chemistry +16

LILRB4-targeting Antibody–Drug Conjugates for the Treatment of Acute Myeloid Leukemia

Yasuaki Anami, Mi Deng, Xun Gui, +6

Molecular Cancer Therapeutics

Hematological MalignancyDrug TargetingMixed-phenotype Acute LeukemiaAcute Myeloid LeukemiaMalignant Blood Disorder +11

Homogeneity of antibody-drug conjugates critically impacts the therapeutic efficacy in brain tumors

Yasuaki Anami, Yoshihiro Otani, Wei Xiong, +7

Cell Reports

An Enzymatically Cleavable Tripeptide Linker for Maximizing the Therapeutic Index of Antibody–Drug Conjugates

Summer Y.Y. Ha, Yasuaki Anami, Chisato M. Yamazaki, +8

Molecular Cancer Therapeutics

A Mixed Population of Antagonist and Agonist Binding Conformers in a Single Crystal Explains Partial Agonism against Vitamin D Receptor: Active Vitamin D Analogues with 22<i>R</i>-Alkyl Group

Yasuaki Anami, Toshimasa Itoh, Daichi Egawa, +2

Journal of Medicinal Chemistry

Molecular BiologyMolecular PharmacologyMedicinal ChemistryConformational SubsetBiochemistry +14

Identification of the Histidine Residue in Vitamin D Receptor That Covalently Binds to Electrophilic Ligands

Mami Yoshizawa, Toshimasa Itoh, Tatsuya HORI, +4

Journal of Medicinal Chemistry

Total Synthesis of the Monomeric Unit of Lomaiviticin A

K. C. Nicolaou, Qi‐Feng Chen, Ruofan Li, +2

Journal of the American Chemical Society

Medicinal ChemistryDiversity Oriented SynthesisBioorganic ChemistryGlycosylationBiochemistry +13