William Fitzpatrick

Fluorine Substitution Can Block CYP3A4 Metabolism-Dependent Inhibition:  Identification of (<i>S</i>)<i>-N</i>-[1-(4-Fluoro-3- morpholin-4-ylphenyl)ethyl]-3- (4-fluorophenyl)acrylamide as an Orally Bioavailable KCNQ2 Opener Devoid of CYP3A4 Metabolism-Dependent Inhibition

Yong‐Jin Wu, Carl D. Davis, Steven I. Dworetzky et al. · Journal of Medicinal Chemistry · 2003 · 58 citations · Full text

Medicine, Pharmacokinetics, Pharmacology +11

(S)-N-[1-(4-Cyclopropylmethyl-3,4-dihydro-2H-benzo[1,4]oxazin-6-yl)-ethyl]-3-(2-fluoro-phenyl)-acrylamide is a potent and efficacious KCNQ2 opener which inhibits induced hyperexcitability of rat hippocampal neurons

Yong‐Jin Wu, Christopher G. Boissard, Jie Chen et al. · Bioorganic & Medicinal Chemistry Letters · 2004 · 27 citations · Full text

Life Sciences, Neuroscience, Pharmacology +11

Synthesis and KCNQ2 opener activity of N-(1-benzo[1,3]dioxol-5-yl-ethyl, N-[1-(2,3-dihydro-benzofuran-5-yl)-ethyl, and N-[1-(2,3-dihydro-1H-indol-5-yl)-ethyl acrylamides

Yong‐Jin Wu, Li‐Qiang Sun, Huan He et al. · Bioorganic & Medicinal Chemistry Letters · 2004 · 18 citations

Natural Sciences, Chemistry, Pharmacology +6

Discovery of (S,E)-3-(2-fluorophenyl)-N-(1-(3-(pyridin-3-yloxy)phenyl)ethyl)-acrylamide as a potent and efficacious KCNQ2 (Kv7.2) opener for the treatment of neuropathic pain

Yong‐Jin Wu, Charles M. Conway, Li‐Qiang Sun et al. · Bioorganic & Medicinal Chemistry Letters · 2013 · 11 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +9