Justin Jackson

Selective inhibition of TGFβ1 activation overcomes primary resistance to checkpoint blockade therapy by altering tumor immune landscape

Constance J. Martin, Abhishek Datta, Christopher Littlefield et al. · Science Translational Medicine · 2020 · 223 citations

Blocking extracellular activation of myostatin as a strategy for treating muscle wasting

Michelle Pirruccello, Justin Jackson, Stefan Wawersik et al. · Scientific Reports · 2018 · 88 citations · Full text

Muscle Function, Human Growth, Immunology +19

Kinetic, Mechanistic, and Structural Modeling Studies of Truncated Wild-Type Leucine-Rich Repeat Kinase 2 and the G2019S Mutant

Min Liu, Stephanie Kang, Soumya S. Ray et al. · Biochemistry · 2011 · 45 citations · Full text

Gtpase Activity, Structural Bioinformatics, Biomolecular Structure Prediction +18

Tolloid cleavage activates latent GDF8 by priming the pro‐complex for dissociation

Viet Q. Le, Roxana E. Iacob, Yuan Tian et al. · The EMBO Journal · 2018 · 33 citations · Full text

Inflammation, Molecular Immunology, Signal Transduction +11

Structural basis of specific inhibition of extracellular activation of pro- or latent myostatin by the monoclonal antibody SRK-015

Kevin B. Dagbay, Erin Treece, Frederick C. Streich et al. · Journal of Biological Chemistry · 2020 · 22 citations · Full text

Skeletal Muscle Growth, Crystal Structure, Human Growth +26