A new method for vitrifying samples for cryoEM

Ivan Razinkov, Venkata P. Dandey, Hui Wei, +6

Journal of Structural Biology

DesiccationMicroscopySample PreparationVitrificationMedicine +2

Interventions and outcomes of patients with multiple myeloma receiving salvage therapy after BCMA-directed CAR T therapy

Oliver Van Oekelen, Karthik Nath, Tarek H. Mouhieddine, +20

Blood

Hematological MalignancyCell TherapyMedicineMalignant Blood DisorderImmunology +10

Mutation-derived Neoantigen-specific T-cell Responses in Multiple Myeloma

Deepak Perumal, Naoko Imai, Alessandro Laganà, +14

Clinical Cancer Research

Patient similarity network of newly diagnosed multiple myeloma identifies patient subgroups with distinct genetic features and clinical implications

Sherry Bhalla, David T. Melnekoff, Adolfo Aleman, +14

Science Advances

Integrative network analysis identifies novel drivers of pathogenesis and progression in newly diagnosed multiple myeloma

Alessandro Laganà, Deepak Perumal, David T. Melnekoff, +15

Leukemia

Hematological MalignancyMedicineBiological NetworkImmunologyCancer Genomics +8

Precision Medicine for Relapsed Multiple Myeloma on the Basis of an Integrative Multiomics Approach

Alessandro Laganà, Itai Beno, David T. Melnekoff, +16

JCO Precision Oncology

EngineeringRelapsed Multiple MyelomaImmunologyPathologyPlasma Cells +16

Sequencing T-cell redirection therapies leads to deep and durable responses in patients with relapsed/refractory myeloma

Tarek H. Mouhieddine, Oliver Van Oekelen, David T. Melnekoff, +19

Blood Advances

Mixed-phenotype Acute LeukemiaImmunologyImmunotherapyDurable ResponsesMyeloid Neoplasia +15

Single-Cell Profiling Reveals Contribution of Tumor Extrinsic and Intrinsic Factors to BCMA-Targeted CAR-T Cell Efficacy in Multiple Myeloma

David T. Melnekoff, Yogita Ghodke‐Puranik, Oliver Van Oekelen, +6

Blood

Multiple Myeloma Risk and Outcomes Are Associated with Pathogenic Germline Variants in DNA Repair Genes

Santiago Thibaud, Ryan L. Subaran, Scott Newman, +21

Blood Cancer Discovery

Pathogenic Germline VariantsGeneticsGenetic EpidemiologyPathologyMultiple Myeloma Risk +14

Immunotherapy-resistant acute lymphoblastic leukemia cells exhibit reduced CD19 and CD22 expression and BTK pathway dependency

Sarah Aminov, Orsi Giricz, David T. Melnekoff, +24

Journal of Clinical Investigation