Thomas Carpenter

Development of a quantitative relationship between CAR-affinity, antigen abundance, tumor cell depletion and CAR-T cell expansion using a multiscale systems PK-PD model

Aman P. Singh, Xirong Zheng, Xiefan Lin‐Schmidt et al. · mAbs · 2019 · 113 citations · Full text

Medicine, Oncology, Pharmacology +17

Development of a Target cell-Biologics-Effector cell (TBE) complex-based cell killing model to characterize target cell depletion by T cell redirecting bispecific agents

Xiling Jiang, Xi Chen, Thomas Carpenter et al. · mAbs · 2018 · 60 citations · Full text

Medicine, Immunology, Pharmacology +17

Bench‐to‐bedside translation of chimeric antigen receptor (CAR) T cells using a multiscale systems pharmacokinetic‐pharmacodynamic model: A case study with anti‐BCMA CAR‐T

Aman P. Singh, Wenbo Chen, Xirong Zheng et al. · CPT Pharmacometrics & Systems Pharmacology · 2021 · 49 citations · Full text

Life Sciences, Immunology, Pharmacokinetics +17

Effects of Topical Nitroglycerin and Intravenous Lidocaine on Propofol-Induced Pain on Injection

Jerome F. O’Hara, Juraj Šprung, Jeffrey T. Laseter et al. · Anesthesia & Analgesia · 1997 · 48 citations

Veterinary Medicine, Anesthesiology, Pharmacology +16

Minimal Physiologically Based Pharmacokinetic-Pharmacodynamic (mPBPK-PD) Model of N-Acetylgalactosamine–Conjugated Small Interfering RNA Disposition and Gene Silencing in Preclinical Species and Humans

Vivaswath S. Ayyar, Dawei Song, Songmao Zheng et al. · Journal of Pharmacology and Experimental Therapeutics · 2021 · 46 citations

Pharmacy, Pharmacokinetics, Pharmacology +17