Large, Diverse Population Cohorts of hiPSCs and Derived Hepatocyte-like Cells Reveal Functional Genetic Variation at Blood Lipid-Associated Loci

Evanthia Pashos, YoSon Park, Xiao Wang, +27

Cell stem cell

Genetic AnalysisAllelic VariantGeneticsGenetic EpidemiologyHuman Polymorphism +6

Pluripotency Redux — Advances in Stem-Cell Research

John D. Gearhart, Evanthia Pashos, Megana Prasad

New England Journal of Medicine

Adult Stem CellStem Cell BiologyDouglas MeltonEmbryologyRegenerative Medicine +15

Functional Analysis and Transcriptomic Profiling of iPSC-Derived Macrophages and Their Application in Modeling Mendelian Disease

Hanrui Zhang, Chenyi Xue, Kate Bermingham, +18

Circulation Research

A Drug Screen using Human iPSC-Derived Hepatocyte-like Cells Reveals Cardiac Glycosides as a Potential Treatment for Hypercholesterolemia

Max A. Cayo, Sunil K. Mallanna, Francesca Di Furio, +14

Cell stem cell

Metabolic SyndromeOxysterolHealth SciencesBiochemistryMedicine +10

GDF15 neutralization restores muscle function and physical performance in a mouse model of cancer cachexia

Ja Young Kim-Muller, LouJin Song, Brianna LaCarubba Paulhus, +15

Cell Reports

Lack of MTTP Activity in Pluripotent Stem Cell-Derived Hepatocytes and Cardiomyocytes Abolishes apoB Secretion and Increases Cell Stress

Ying Liu, Donna Conlon, Xin Bi, +14

Cell Reports

Mttp ActivityInduced Pluripotent Stem CellMedicinePhysiologyCell Death +10

BDK inhibition acts as a catabolic switch to mimic fasting and improve metabolism in mice

Eliza Bollinger, Matthew Peloquin, Jenna Libera, +23

Molecular Metabolism

Interrogation of the Atherosclerosis-Associated <i>SORT1</i> (Sortilin 1) Locus With Primary Human Hepatocytes, Induced Pluripotent Stem Cell-Hepatocytes, and Locus-Humanized Mice

Xiao Wang, Avanthi Raghavan, Derek Peters, +3

Arteriosclerosis Thrombosis and Vascular Biology

Genetic or therapeutic neutralization of ALK1 reduces LDL transcytosis and atherosclerosis in mice

Sungwoon Lee, Hubertus Schleer, Hyojin Park, +19

Nature Cardiovascular Research

ATP-Binding Cassette Transporter A1 Deficiency in Human Induced Pluripotent Stem Cell-Derived Hepatocytes Abrogates HDL Biogenesis and Enhances Triglyceride Secretion

Xin Bi, Evanthia Pashos, Marina Cuchel, +13

EBioMedicine

ImmunologyHyperlipidemiaCellular PhysiologyEnhances Triglyceride SecretionStem Cells +19