mTOR supports long-term self-renewal and suppresses mesoderm and endoderm activities of human embryonic stem cells

Jiaxi Zhou, Pei Su, Lu Wang, +11

Proceedings of the National Academy of Sciences

Long-term Self-renewalAdult Stem CellMtor Impairs PluripotencyEndoderm ActivitiesSuppresses Mesoderm +17

Induction of PDCD4 tumor suppressor gene expression by RAR agonists, antiestrogen and HER-2/neu antagonist in breast cancer cells. Evidence for a role in apoptosis

Olubunmi Afonja, Dominique Juste, Sharmistha Das, +2

Oncogene

Her-2/neu AntagonistBreast OncologyMedicineApoptosisImmunology +10

RAR agonists stimulate SOX9 gene expression in breast cancer cell lines: evidence for a role in retinoid-mediated growth inhibition

Olubunmi Afonja, Bruce M. Raaka, Ambrose J. Huang, +5

Oncogene

Sox9 Gene ExpressionRetinoid-mediated Growth InhibitionMedicineRar AgonistsCell Proliferation +10

Alterations in the expression of PDCD4 in ductal carcinoma of the breast

Yong Wen, Xiuquan Shi, Luis Chiriboga, +3

Oncology Reports

MEIS1 and HOXA7 genes in human acute myeloid leukemia

Olubunmi Afonja, John E. Smith, Debbie M. Cheng, +8

Leukemia Research

Programmed cell death 4 enhances chemosensitivity of ovarian cancer cells by activating death receptor pathway <i>in vitro</i> and <i>in vivo</i>

Xia Zhang, Xiaoyan Wang, Xingguo Song, +7

Cancer Science

Multilineage involvement and erythropoietin-"independent" erythroid progenitor cells in a patient with systemic mastocytosis

Olubunmi Afonja, Edward L. Amorosi, LK Ashman, +1

Annals of Hematology

Autoimmune DiseaseCell DivisionMast Cell DisorderSystemic MastocytosisImmunology +6

S264: EDIT-301 SHOWS PROMISING PRELIMINARY SAFETY AND EFFICACY RESULTS IN THE PHASE I/II CLINICAL TRIAL (RUBY) OF PATIENTS WITH SEVERE SICKLE CELL DISEASE USING HIGHLY SPECIFIC AND EFFICIENT ASCAS12A ENZYME

Rabi Hanna, Haydar Frangoul, Christopher Mckinney, +9

HemaSphere

AsCas12a Gene Editing of <i>HBG1/2</i> Promoters with EDIT-301 Results in Rapid and Sustained Normalization of Hemoglobin and Increased Fetal Hemoglobin in Patients with Severe Sickle Cell Disease and Transfusion-Dependent Beta-Thalassemia

Rabi Hanna, Haydar Frangoul, Christopher McKinney, +12

Blood

Characterizing female patients with haemophilia A: Administrative claims analysis and medical chart review

Ryan Farej, Katharine Batt, Olubunmi Afonja, +5

Haemophilia