John E. Smith

Congenital Titinopathy: Comprehensive characterization and pathogenic insights

Emily C. Oates, Kristi Jones, Sandra Donkervoort et al. · Annals of Neurology · 2018 · 152 citations · Full text

Experimentally Increasing Titin Compliance in a Novel Mouse Model Attenuates the Frank-Starling Mechanism But Has a Beneficial Effect on Diastole

Mei Methawasin, Kirk R. Hutchinson, Eun‐Jeong Lee et al. · Circulation · 2014 · 141 citations · Full text

The giant protein titin regulates the length of the striated muscle thick filament

Paola Tonino, Balázs Kiss, Joshua Strom et al. · Nature Communications · 2017 · 103 citations · Full text

Deleting titin’s I-band/A-band junction reveals critical roles for titin in biomechanical sensing and cardiac function

Henk Granzier, Kirk R. Hutchinson, Paola Tonino et al. · Proceedings of the National Academy of Sciences · 2014 · 98 citations · Full text

Shortening of the Elastic Tandem Immunoglobulin Segment of Titin Leads to Diastolic Dysfunction

Charles S. Chung, Kirk R. Hutchinson, Mei Methawasin et al. · Circulation · 2013 · 97 citations · Full text