Delta-like 4 is indispensable in thymic environment specific for T cell development

Katsuto Hozumi, Carolina Mailhos, Naoko Negishi, +7

The Journal of Experimental Medicine

Dll4 ExpressionLymphocyte DevelopmentAdaptive Immune SystemT-regulatory CellImmunology +16

Wnt glycoproteins regulate the expression of FoxN1, the gene defective in nude mice

Gina Balc̆iūnaite, Marcel P. Keller, Egle Balciunaite, +7

Nature Immunology

Knockout MouseTranscriptional RegulationNude MiceGeneticsGene Regulation +7

Normal Thymic Architecture and Negative Selection Are Associated with <i>Aire</i> Expression, the Gene Defective in the Autoimmune-Polyendocrinopathy-Candidiasis-Ectodermal Dystrophy (APECED)

Saulius Žuklys, Gina Balc̆iūnaite, Anni Agarwal, +3

The Journal of Immunology

Lymphocyte DevelopmentImmunodeficienciesGeneticsImmunologyImmune Regulation +25

Monoallelic Expression of the Interleukin-2 Locus

Georg A. Holländer, Saulius Žuklys, Corinne Morel, +8

Science

T-regulatory CellImmunologyImmune RegulationIl-2 ResultsImmunotherapy +14

Keratinocyte growth factor (KGF) enhances postnatal T-cell development via enhancements in proliferation and function of thymic epithelial cells

Simona W. Rossi, Lukas T. Jeker, Tomoo Ueno, +8

Blood

Foxn1 regulates key target genes essential for T cell development in postnatal thymic epithelial cells

Saulius Žuklys, Adam E. Handel, Saule Zhanybekova, +10

Nature Immunology

T Cell DevelopmentDevelopmental BiologyKey Target GenesCell RegulationLymphocyte Development +7

The thymic epithelial microRNA network elevates the threshold for infection-associated thymic involution via miR-29a mediated suppression of the IFN-α receptor

Aikaterini S. Papadopoulou, James Dooley, Michelle A. Linterman, +9

Nature Immunology

Immune Cell DevelopmentPathogenesisImmune RegulationImmunologyImmune Surveillance +12

Aire-expressing thymic medullary epithelial cells originate from β5t-expressing progenitor cells

Izumi Ohigashi, Saulius Žuklys, Mie Sakata, +6

Proceedings of the National Academy of Sciences

Adult Thymic Medullary Epithelium Is Maintained and Regenerated by Lineage-Restricted Cells Rather Than Bipotent Progenitors

Izumi Ohigashi, Saulius Žuklys, Mie Sakata, +5

Cell Reports

Stabilized β-Catenin in Thymic Epithelial Cells Blocks Thymus Development and Function

Saulius Žuklys, Jason Gill, Marcel P. Keller, +11

The Journal of Immunology