Receptor Tyrosine Kinases Activate Canonical WNT/β-Catenin Signaling via MAP Kinase/LRP6 Pathway and Direct β-Catenin Phosphorylation

Pavel Krejčı́, Anie Aklian, Markéta Kaucká, +17

PLoS ONE

Molecular RegulationDirect β-Catenin PhosphorylationSynaptic SignalingCellular PhysiologyTumor Biology +17

Multikinase activity of fibroblast growth factor receptor (FGFR) inhibitors SU5402, PD173074, AZD1480, AZD4547 and BGJ398 compromises the use of small chemicals targeting FGFR catalytic activity for therapy of short-stature syndromes

Iva Gudernová, Iva Veselá, Lukáš Bálek, +8

Human Molecular Genetics

Multikinase ActivityFgfr TkisPathologyCell ProliferationFgfr Catalytic Activity +14

Fibroblast growth factor and canonical WNT/β-catenin signaling cooperate in suppression of chondrocyte differentiation in experimental models of FGFR signaling in cartilage

Marcela Buchtová, Veronika Oralová, Anie Aklian, +19

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease

Developmental BiologyBone Morphogenic ProteinMedicineCartilage DegenerationFibroblast Growth Factor +8

An inactivating mutation in intestinal cell kinase,<i>ICK</i>, impairs hedgehog signalling and causes short rib-polydactyly syndrome

S. Paige Taylor, Michaela Kunova Bosakova, Miroslav Vařecha, +17

Human Molecular Genetics

GeneticsPathologyMolecular GeneticsInactivating MutationDisease Gene Identification +21

The inositol phosphatase SHIP2 enables sustained ERK activation downstream of FGF receptors by recruiting Src kinases

Bohumil Fafílek, Lukáš Bálek, Michaela Kunova Bosakova, +17

Science Signaling

Fibroblast growth factor receptor influences primary cilium length through an interaction with intestinal cell kinase

Michaela Kunova Bosakova, Alexandru Niţă, Tomáš Gregor, +25

Proceedings of the National Academy of Sciences

A novel variant of FGFR3 causes proportionate short stature

Sarina G. Kant, Iveta Cervenkova, Lukáš Bálek, +12

European Journal of Endocrinology

Nanodiamonds as “artificial proteins”: Regulation of a cell signalling system using low nanomolar solutions of inorganic nanocrystals

Lukáš Bálek, Marcela Buchtová, Michaela Kunova Bosakova, +14

Biomaterials

One reporter for in-cell activity profiling of majority of protein kinase oncogenes

Iva Gudernová, Silvie Foldynová-Trantírková, Barbora El Ghannamova, +9

eLife

Statins do not inhibit the FGFR signaling in chondrocytes

Bohumil Fafílek, Marek Hampl, Nikola Řičánková, +6

Osteoarthritis and Cartilage

SclerostinCartilage DegenerationOsteoarthritisFibroblast Growth FactorMedicine +3