George A. Garcia

AI is a viable alternative to high throughput screening: a 318-target study

Izhar Wallach, Denzil Bernard, Kong T. Nguyen et al. · Scientific Reports · 2024 · 120 citations · Full text

Pharmacy, Bioinformatics, Medicinal Chemistry +16

Structural basis for rifamycin resistance of bacterial RNA polymerase by the three most clinically important RpoB mutations found in <i>Mycobacterium tuberculosis</i>

Vadim Molodtsov, Nathan T. Scharf, Maxwell Stefan et al. · Molecular Microbiology · 2016 · 114 citations · Full text

Life Sciences, Molecular Biology, Antimicrobial Resistance +15

Confirmation of a second natural preQ₁ aptamer class in Streptococcaceae bacteria

Michelle M. Meyer, Adam Roth, Stephanie M. Chervin et al. · RNA · 2008 · 113 citations · Full text

Life Sciences, Microbiology, Molecular Biology +13

Virtual Screening for Submicromolar Leads of tRNA-guanine Transglycosylase Based on a New Unexpected Binding Mode Detected by Crystal Structure Analysis

Ruth Brenk, Ulrich Grädler, Hans‐Dieter Gerber et al. · Journal of Medicinal Chemistry · 2003 · 103 citations · Full text

Pharmacy, Medicinal Chemistry, Molecular Biology +16

A new target for shigellosis: rational design and crystallographic studies of inhibitors of tRNA-guanine transglycosylase11Edited by R. Huber

Ulrich Grädler, Hans‐Dieter Gerber, DeeAnne M Goodenough-Lashua et al. · Journal of Molecular Biology · 2001 · 76 citations

Pharmacy, Biochemistry, Molecular Biology +7