Kevin W. Tipping

pH-induced molecular shedding drives the formation of amyloid fibril-derived oligomers

Kevin W. Tipping, Theodoros K. Karamanos, Toral Jakhria et al. · Proceedings of the National Academy of Sciences · 2015 · 111 citations · Full text

RAS-inhibiting biologics identify and probe druggable pockets including an SII-α3 allosteric site

Katarzyna Z. Haza, Heather L. Martin, Ajinkya Rao et al. · Nature Communications · 2021 · 42 citations · Full text

β2-Microglobulin Amyloid Fibril-Induced Membrane Disruption Is Enhanced by Endosomal Lipids and Acidic pH

Sophia C. Goodchild, Tania Sheynis, Rebecca F. Thompson et al. · PLoS ONE · 2014 · 39 citations · Full text

Proteinlipid Interaction, Endosomal Lipids, Biochemistry +15

β2-Microglobulin Amyloid Fibrils Are Nanoparticles That Disrupt Lysosomal Membrane Protein Trafficking and Inhibit Protein Degradation by Lysosomes

Toral Jakhria, Andrew L. Hellewell, Morwenna Y. Porter et al. · Journal of Biological Chemistry · 2014 · 36 citations · Full text

Protein Nanoparticles, Protein Folding, Natural Sciences +10

Aggregation Modulators Interfere with Membrane Interactions of β2-Microglobulin Fibrils

Tania Sheynis, Anat Friediger, Wei‐Feng Xue et al. · Biophysical Journal · 2013 · 29 citations · Full text