Unconventional initiation of PINK1/Parkin mitophagy by Optineurin

Thanh Ngoc Nguyen, Justyna Sawa‐Makarska, Grace Khuu, +10

Molecular Cell

Small heat shock proteins operate as molecular chaperones in the mitochondrial intermembrane space

Elias Adriaenssens, Bob Asselbergh, Pablo Rivera-Mejías, +9

Nature Cell Biology

Axonal Neuropathies due to Mutations in Small Heat Shock Proteins: Clinical, Genetic, and Functional Insights into Novel Mutations

Andoni Echaniz‐Laguna, Thomas Geuens, Philippe Petiot, +18

Human Mutation

GeneticsNeurochemical BiomarkersDisease Gene IdentificationHspb8 MutationsSynaptic Signaling +15

Neuropathy-causing mutations in HSPB1 impair autophagy by disturbing the formation of SQSTM1/p62 bodies

Mansour Haidar, Bob Asselbergh, Elias Adriaenssens, +5

Autophagy

MitophagyHspb1 LeadImmunologyCell DeathAutophagy Deficits +19

Partial Inhibition of Glycolysis Reduces Atherogenesis Independent of Intraplaque Neovascularization in Mice

Paola Perrotta, Bieke Van der Veken, Pieter Van der Veken, +7

Arteriosclerosis Thrombosis and Vascular Biology

Molecular Chaperones in the Pathogenesis of Amyotrophic Lateral Sclerosis: The Role of HSPB1

Simona Capponi, Thomas Geuens, Alessandro Geroldi, +12

Human Mutation

Neurodegenerative DiseasesMolecular ChaperonesAmyotrophic Lateral SclerosisCandidate Gene Hspb1Hspb1 Mutations +12

NDP52 acts as a redox sensor in PINK1/Parkin‐mediated mitophagy

Tetsushi Kataura, Elsje G. Otten, Yoana Rabanal‐Ruiz, +13

The EMBO Journal

Biallelic VARS variants cause developmental encephalopathy with microcephaly that is recapitulated in vars knockout zebrafish

Aleksandra Siekierska, Hannah Stamberger, Tine Deconinck, +71

Nature Communications

Induced pluripotent stem cell-derived motor neurons of CMT type 2 patients reveal progressive mitochondrial dysfunction

Jonas Van Lent, Peter Verstraelen, Bob Asselbergh, +8

Brain

Neurodegenerative DiseasesGene TherapiesDevelopmental BiologyMitochondrial FunctionMedicine +13

BAG3 Pro209 mutants associated with myopathy and neuropathy relocate chaperones of the CASA-complex to aggresomes

Elias Adriaenssens, B. Tedesco, Laura Mediani, +6

Scientific Reports