Activation of the AXL kinase causes resistance to EGFR-targeted therapy in lung cancer

Zhenfeng Zhang, Jae Cheol Lee, Luping Lin, +27

Nature Genetics

OncologyAxl KinaseEgfr-targeted TherapyMedicineBronchial Neoplasm +6

Exosomal PD-L1 promotes tumor growth through immune escape in non-small cell lung cancer

Dong Ha Kim, HyeongRyul Kim, Yun Jung Choi, +14

Experimental & Molecular Medicine

RETRACTED ARTICLE: EGFR and MET receptor tyrosine kinase–altered microRNA expression induces tumorigenesis and gefitinib resistance in lung cancers

Michela Garofalo, Giulia Romano, Gianpiero Di Leva, +14

Nature Medicine

Epithelial to mesenchymal transition derived from repeated exposure to gefitinib determines the sensitivity to EGFR inhibitors in A549, a non-small cell lung cancer cell line

Jin Kyung Rho, Yun Jung Choi, Jin Kyung Lee, +5

Lung Cancer

MedicineEgfr InhibitorsEpithelial-mesenchymal InteractionsBronchial NeoplasmCancer Biology +5

Upregulation of CXCR4 is functionally crucial for maintenance of stemness in drug-resistant non-small cell lung cancer cells

M.-s. Jung, Jin Kyung Rho, Yong‐Mi Kim, +7

Oncogene

Tumor BiologyMedicineStem Cell MobilizationStem CellsStem Cell Research +7

Clinical and molecular evidences of epithelial to mesenchymal transition in acquired resistance to EGFR-TKIs

Jin-Haeng Chung, Jin Kyung Rho, Xianhua Xu, +1

Lung Cancer

Epithelial-mesenchymal TransitionMolecular EvidencesReceptor Tyrosine KinaseMesenchymal TransitionPathology +8

MET and AXL Inhibitor NPS-1034 Exerts Efficacy against Lung Cancer Cells Resistant to EGFR Kinase Inhibitors Because of MET or AXL Activation

Jin Kyung Rho, Yun Jung Choi, Seon Ye Kim, +8

Cancer Research

Met ActivationOncologyAxl ActivationMet AmplificationNovel Therapy +13

p53 Enhances Gefitinib-Induced Growth Inhibition and Apoptosis by Regulation of Fas in Non–Small Cell Lung Cancer

Jin Kyung Rho, Yun Jung Choi, Baek‐Yeol Ryoo, +4

Cancer Research

Cell DeathPathologyCancer BiologyTumor BiologyOncology +14

Epithelial‐mesenchymal transition leads to crizotinib resistance in H2228 lung cancer cells with EML4‐ALK translocation

Hyeong Ryul Kim, Woo Sung Kim, Yun Jung Choi, +3

Molecular Oncology

Tumor-derived exosomal miR-619-5p promotes tumor angiogenesis and metastasis through the inhibition of RCAN1.4

Dong Ha Kim, Sojung Park, HyeongRyul Kim, +11

Cancer Letters

Tumor BiologyAngiogenesisMedicineCancer Cell BiologyExtracellular Microvesicles +5