Negative regulation of PI3K/AKT/mTOR axis regulates fibroblast proliferation, apoptosis and autophagy play a vital role in triptolide-induced epidural fibrosis reduction

Jihang Dai, Yu Sun, Duoyun Chen, +4

European Journal of Pharmacology

InflammationCell AutophagyMitophagySignal TransductionSignaling Pathway +11

Glabridin inhibits osteoarthritis development by protecting chondrocytes against oxidative stress, apoptosis and promoting mTOR mediated autophagy

Jihang Dai, Yaxin Zhang, Deng Chen, +4

Life Sciences

InflammationAnti-inflammatoryMedicineAutophagyCartilage Degeneration +7

Scutellarin inhibits RANKL-mediated osteoclastogenesis and titanium particle-induced osteolysis via suppression of NF-κB and MAPK signaling pathway

Shuai Zhao, Yu Sun, Xiaolei Li, +7

International Immunopharmacology

SclerostinOsteoarthritisTitanium Particle-induced OsteolysisOsteoporosisBone Homeostasis +7

Sinensetin attenuates IL-1β-induced cartilage damage and ameliorates osteoarthritis by regulating SERPINA3

Zhendong Liu, Ruizhou Liu, Rui Wang, +4

Food & Function

Local application of rapamycin reduces epidural fibrosis after laminectomy via inhibiting fibroblast proliferation and prompting apoptosis

Yu Sun, Shuai Zhao, Xiaolei Li, +6

Journal of Orthopaedic Surgery and Research

Apigenin inhibits fibroblast proliferation and reduces epidural fibrosis by regulating Wnt3a/β-catenin signaling pathway

Rui Jiao, Hui Chen, Qi Wan, +5

Journal of Orthopaedic Surgery and Research

Risk factors for femoral neck fracture in elderly population.

Pengran Liu, Yaxin Zhang, Binlei Sun, +3

PubMed

Homoharringtonine inhibits fibroblasts proliferation, extracellular matrix production and reduces surgery-induced knee arthrofibrosis via PI3K/AKT/mTOR pathway-mediated apoptosis

Yu Sun, Jihang Dai, Rui Jiao, +2

Journal of Orthopaedic Surgery and Research

Homoharringtonine prevents surgery-induced epidural fibrosis through endoplasmic reticulum stress signaling pathway

Xiaolei Li, Shuguang Wang, Jihang Dai, +4

European Journal of Pharmacology

Molecular NeuroscienceSpinal Cord InjuryMedicinePhysiologyEndoplasmic Reticulum Stress +2

Tamoxifen inhibits fibroblast proliferation and prevents epidural fibrosis by regulating the AKT pathway in rats

Shuguang Wang, Xiaolei Li, Lianqi Yan, +5

Biochemical and Biophysical Research Communications

InflammationTamoxifen InhibitsFibrosisUterine FibroidsMedicine +9