Kari Vastag

Species differences in the pharmacokinetics and metabolism of indinavir, a potent human immunodeficiency virus protease inhibitor.

Jiunn H. Lin, Masato Chiba, Suresh K. Balani et al. · Drug Metabolism and Disposition · 1996 · 153 citations

Pharmacy, Pharmacokinetics, Pharmacology +14

Efficacious, Orally Bioavailable Thrombin Inhibitors Based on 3-Aminopyridinone or 3-Aminopyrazinone Acetamide Peptidomimetic Templates

Philip E.J. Sanderson, Terry A. Lyle, Kellie J. Cutrona et al. · Journal of Medicinal Chemistry · 1998 · 85 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +14

pH-dependent oral absorption of L-735,524, a potent HIV protease inhibitor, in rats and dogs.

Jiunn H. Lin, I W Chen, Kari Vastag et al. · Drug Metabolism and Disposition · 1995 · 80 citations

Pharmacy, Pharmacokinetics, Pharmacology +16

Discovery and Development of the Novel Potent Orally Active Thrombin Inhibitor <i>N</i>-(9-Hydroxy-9-fluorenecarboxy)prolyl <i>trans</i>-4-Aminocyclohexylmethyl Amide (L-372,460):  Coapplication of Structure-Based Design and Rapid Multiple Analogue Synthesis on Solid Support

Stephen F. Brady, Kenneth J. Stauffer, William C. Lumma et al. · Journal of Medicinal Chemistry · 1998 · 78 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17

L-374,087, an efficacious, orally bioavailable, pyridinone acetamide thrombin inhibitor

Philip E.J. Sanderson, Kellie J. Cutrona, Bruce D. Dorsey et al. · Bioorganic & Medicinal Chemistry Letters · 1998 · 69 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +9