Progenitor and Terminal Subsets of CD8 ⁺ T Cells Cooperate to Contain Chronic Viral Infection

Michael Paley, Daniela C. Kroy, Pamela M. Odorizzi, +8

Science

Adaptive Immune SystemT CellsChronic InfectionImmune RegulationImmunology +13

Transcriptional analysis of HIV-specific CD8+ T cells shows that PD-1 inhibits T cell function by upregulating BATF

Michael Quigley, Florencia Pereyra, Björn Nilsson, +23

Nature Medicine

Transcriptional AnalysisHuman RetrovirusT-regulatory CellImmunologyAntiviral Response +7

Multifactorial T-cell Hypofunction That Is Reversible Can Limit the Efficacy of Chimeric Antigen Receptor–Transduced Human T cells in Solid Tumors

Edmund K. Moon, Liang-Chuan Wang, Douglas V. Dolfi, +11

Clinical Cancer Research

Circulating CXCR5+PD-1+ Response Predicts Influenza Vaccine Antibody Responses in Young Adults but not Elderly Adults

Ramin S. Herati, Morgan A. Reuter, Douglas V. Dolfi, +10

The Journal of Immunology

Young AdultsImmunologyCd4 T Cell ResponsesFlu VaccinationImmunotherapy +14

Perforin and IL-2 Upregulation Define Qualitative Differences among Highly Functional Virus-Specific Human CD8+ T Cells

George Makedonas, Natalie A. Hutnick, Danielle Haney, +8

PLoS Pathogens

Increased T-bet is associated with senescence of influenza virus-specific CD8 T cells in aged humans

Douglas V. Dolfi, Kathleen D. Mansfield, Antonio Polley, +5

Journal of Leukocyte Biology

Bystander Chronic Infection Negatively Impacts Development of CD8+ T Cell Memory

Erietta Stelekati, Haina Shin, Travis A. Doering, +13

Immunity

Autoimmune DiseaseT-regulatory CellImmunologyBystander Chronic InfectionAutoimmunity +4

Persistent Enteric Murine Norovirus Infection Is Associated with Functionally Suboptimal Virus-Specific CD8 T Cell Responses

Vesselin T. Tomov, Lisa C. Osborne, Douglas V. Dolfi, +6

Journal of Virology

Late Signals from CD27 Prevent Fas-Dependent Apoptosis of Primary CD8+ T Cells

Douglas V. Dolfi, Alina C. Boesteanu, Constantinos Petrovas, +3

The Journal of Immunology

Dendritic Cells and CD28 Costimulation Are Required To Sustain Virus-Specific CD8+ T Cell Responses during the Effector Phase In Vivo

Douglas V. Dolfi, Priyanka Duttagupta, Alina C. Boesteanu, +4

The Journal of Immunology

Effector PhaseAdaptive Immune SystemImmunologyImmunologic MechanismCd4 T Cell Responses +15